Structure and Function of Macroalgal Natural Products

Young, Ryan M.; Schoenrock, Kathryn M.; Salm, Jacqueline L. von; Amsler, Charles D.; Baker, Bill J.

doi:10.1007/978-1-4939-2684-8_2

Cited by 38 publications

(7 citation statements)

References 240 publications

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“…Among all species living in the oceans, seaweed is a promising source of new bioactive and pharmacological compounds [7]. Seaweeds are photosynthetic autotrophic organisms classified into different taxonomic groups, which produce a range of chemically distinct compounds [8]. Some of these compounds are not present in plants and have bioactive potential, of interest for pharmaceutics, cosmetics, and nutrition [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Marine Alkaloids with Anti-Inflammatory Activity: Current Knowledge and Future Perspectives

2020

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Alkaloids are nitrogenous compounds with various biological activities. Alkaloids with anti-inflammatory activity are commonly found in terrestrial plants, but there are few records of the identification and characterization of the activity of these compounds in marine organisms such as fungi, bacteria, sponges, ascidians, and cnidarians. Seaweed are a source of several already elucidated bioactive compounds, but few studies have described and characterized the activity of seaweed alkaloids with anti-inflammatory properties. In this review, we have gathered the current knowledge about marine alkaloids with anti-inflammatory activity and suggest future perspectives for the study and bioprospecting of these compounds.

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Section: Introductionmentioning

confidence: 99%

Marine Alkaloids with Anti-Inflammatory Activity: Current Knowledge and Future Perspectives

2020

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“…Marine algal metabolites account for 13% of marine natural products, with terpenoids prevailing at a percentage over 50% [ 8 , 9 ]. Geranylgeraniol derivatives comprise some of the earliest compounds isolated from the order Fucales that comprise about a third of brown algal metabolites [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Bifurcatriol, a New Antiprotozoal Acyclic Diterpene from the Brown Alga Bifurcaria bifurcata

et al. 2017

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Linear diterpenes that are commonly found in brown algae are of high chemotaxonomic and ecological importance. This study reports bifurcatriol (1), a new linear diterpene featuring two stereogenic centers isolated from the Irish brown alga Bifurcaria bifurcata. The gross structure of this new natural product was elucidated based on its spectroscopic data (IR, 1D and 2D-NMR, HRMS). Its absolute configuration was identified by experimental and computational vibrational circular dichroism (VCD) spectroscopy, combined with the calculation of 13C-NMR chemical shielding constants. Bifurcatriol (1) was tested for in vitro antiprotozoal activity towards a small panel of parasites (Plasmodium falciparum, Trypanosoma brucei rhodesiense, T. cruzi, and Leishmania donovani) and cytotoxicity against mammalian primary cells. The highest activity was exerted against the malaria parasite P. falciparum (IC50 value 0.65 μg/mL) with low cytotoxicity (IC50 value 56.6 μg/mL). To our knowledge, this is the first successful application of VCD and DP4 probability analysis of the calculated 13C-NMR chemical shifts for the simultaneous assignment of the absolute configuration of multiple stereogenic centers in a long-chain acyclic natural product.

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“…In summary, distribution records for kelp have fluctuated over time in terms of recording effort and regions visited. The focus of study has progressed from basic species description and use as a resource from the 1700s–1910s, expanding to disciplines like ecology, evolution, and natural product chemistry which are facilitated by technology (Young et al, 2015). Present‐day investigations utilize species distribution models to project future distributions of seaweeds based on the habitat suitability or environmental forcing associated with records of species presence.…”

Section: Historical Records 1900–2018mentioning

confidence: 99%

A review of subtidal kelp forests in Ireland: From first descriptions to new habitat monitoring techniques

Schoenrock

Chan

O'Callaghan

et al. 2020

Ecology and Evolution

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Aim Kelp forests worldwide are important marine ecosystems that foster high primary to secondary productivity and multiple ecosystem services. These ecosystems are increasingly under threat from extreme storms, changing ocean temperatures, harvesting, and greater herbivore pressure at regional and global scales, necessitating urgent documentation of their historical to present‐day distributions. Species range shifts to higher latitudes have already been documented in some species that dominate subtidal habitats within Europe. Very little is known about kelp forest ecosystems in Ireland, where rocky coastlines are dominated by Laminaria hyperborea. In order to rectify this substantial knowledge gap, we compiled historical records from an array of sources to present historical distribution, kelp and kelp forest recording effort over time, and present rational for the monitoring of kelp habitats to better understand ecosystem resilience. Location Ireland (Northern Ireland and Éire). Methods Herbaria, literature from the Linnaean society dating back to late 1700s, journal articles, government reports, and online databases were scoured for information on L. hyperborea. Information about kelp ecosystems was solicited from dive clubs and citizen science groups that are active along Ireland's coastlines. Results Data were used to create distribution maps and analyze methodology and technology used to record L. hyperborea presence and kelp ecosystems within Ireland. We discuss the recent surge in studies on Irish kelp ecosystems, fauna associated with kelp ecosystems that may be used as indicators of ecosystem health and suggest methodologies for continued monitoring. Main Conclusions While there has been a steady increase in recording effort of the dominant subtidal kelp forest species, L. hyperborea, only recently have studies begun to address other important eco‐evolutionary processes at work in kelp forests including connectivity among kelp populations in Ireland. Further monitoring, using suggested methodologies, is required to better understand the resilience of kelp ecosystems in Ireland.

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Structure and Function of Macroalgal Natural Products

Cited by 38 publications

References 240 publications

Marine Alkaloids with Anti-Inflammatory Activity: Current Knowledge and Future Perspectives

Marine Alkaloids with Anti-Inflammatory Activity: Current Knowledge and Future Perspectives

Bifurcatriol, a New Antiprotozoal Acyclic Diterpene from the Brown Alga Bifurcaria bifurcata

A review of subtidal kelp forests in Ireland: From first descriptions to new habitat monitoring techniques

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