Structure and Function of Human and Murine Receptors for IgG

Unkeless, Jay C.; Scigliano, Eileen; Freedman, Victoria H.

doi:10.1146/annurev.iy.06.040188.001343

Cited by 456 publications

(149 citation statements)

References 74 publications

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“…So far, our Fc␥BPf expressed in COS and CHO cells is also recovered as broad bands of 50 -80 kDa under reduced conditions by Western blot analysis. 3 Physiological Functions of Fc␥BP-Our previous study using monoclonal antibodies showed the presence of Fc␥BP in the mucosa of the large and small intestines (13,14). In the present study, Fc␥BP mRNA is detected not only in the colorectal epithelial cells but also in the placenta (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…For example, immunoglobulin G (IgG) complexes evoke numerous functions. They are phagocytosed by macrophages, activate the lytic potential of cytotoxic lymphocytes and monocytes, and regulate B lymphocyte activation via different receptors for IgGFc (Fc␥R) expressed on different cells (3,4). Soluble forms of FcR, called immunoglobulin-binding factors, may also be involved in regulatory functions (5).…”

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confidence: 99%

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Human IgGFc Binding Protein (FcγBP) in Colonic Epithelial Cells Exhibits Mucin-like Structure

Harada¹,

Iijima²,

Kobayashi³

et al. 1997

Journal of Biological Chemistry

104

127

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Human IgGFc Binding Protein (FcγBP) in Colonic Epithelial Cells Exhibits Mucin-like Structure

Harada¹,

Iijima²,

Kobayashi³

et al. 1997

Journal of Biological Chemistry

104

127

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“…FcyR are heterogeneous and three classes have been described on human leukocytes, FcyRI (CD64), FcyRII (CD32), and FcyRIII (CD16). They can be distinguished on the basis of molecular weight, cellular distribution, affinity and specificity for IgG isotypes, and recognition by mAbs (1,2). During the last few years knowledge about these receptors has increased rapidly, and cDNAs have been cloned for all types (3)(4)(5)(6)(7)(8) .…”

Section: Discussionmentioning

confidence: 99%

Molecular basis for a polymorphism of human Fc gamma receptor II (CD32).

Warmerdam¹,

Winkel²,

Gosselin³

et al. 1990

The Journal of Experimental Medicine

284

167

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SummaryThe IgG Fc receptor II on human monocytes is polymorphic in its ability to bind mIgG1, and its isoelectric focusing pattern. To study the molecular basis of this polymorphism, a cDNA library from cell line K562, expressing two different allelic forms (high responder [HR] and low responder [LR]) of FcyRII, was used for cDNA cloning. We report the isolation and identification of different FcyRII cDNA clones, comprising the LR form of FcyRII, as was evident from studies using a new HRspecific anti-FcyRII mAb 41H16, and from rosetting experiments . Sequence analysis revealed that HR and LR forms differ by two amino acids, both located in the external domain. In the cloned LR form, a glutamine is substituted by a tryptophan residue at as position 27, located in the first Ig-like domain, and an arginine residue by a histidine residue at as position 131 in the second Ig-like domain. Furthermore, an FcyRII cDNA clone was isolated with a deletion of 123 bp, overlapping the predicted transmembrane segment . Data showing the presence of an alternatively spliced mRNA detectedby using polymerase chain reaction (PCR) might suggest the existence of a soluble form of the human FcyRII, in addition to the membrane-bound forms .

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“…The rosetting method used here does not distinguish between types of Fc receptor. In any case, murine Fc receptors are probably not entirely isotype specific (Unkeless et al, 1988;Takizawa et al, 1992). Consequently one cannot predict in detail the effect of altered Fc receptor expression on macrophage behaviour.…”

Section: Discussionmentioning

confidence: 99%

Immunological activities of a lymphocyte mitogen isolated from coenurus fluid ofTaenia multiceps(Cestoda)

1997

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Summary :The purification of a mitogen from Taenia multiceps coenurus fluid has been previously reported. In the present study, this activity, which was independent of endotoxin, stimulated the expression of lymphocyte IL-2 and Fc receptors, enhanced mitotic response to phytohaemagglutinin and concanavalin A and antagonised the previously described suppressive effects of the macrophage modifying fraction of coenurus fluid. The mitogen also increased peritoneal macrophage count and viability, Fc receptor expression and Fc receptor-mediated phagocytosis. The mitogenic activity could be destroyed by a combination of protease and amylase, but not by either enzyme alone. It is suggested that the mitogen forms part of a homeostatic mechanism for the preservation of a balanced host-parasite relationship.KEY WORDS : Taenia, coenurus, immunoregulation, macrophage, Τ cell, Fc, C3b, histocompatibility antigen, phagocyte, enzyme, Echinococcus, hydatid. Résumé: LES EFFETS IMMUNOLOGIQUES

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Structure and Function of Human and Murine Receptors for IgG

Cited by 456 publications

References 74 publications

Human IgGFc Binding Protein (FcγBP) in Colonic Epithelial Cells Exhibits Mucin-like Structure

Human IgGFc Binding Protein (FcγBP) in Colonic Epithelial Cells Exhibits Mucin-like Structure

Molecular basis for a polymorphism of human Fc gamma receptor II (CD32).

Immunological activities of a lymphocyte mitogen isolated from coenurus fluid ofTaenia multiceps(Cestoda)

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