Structure and expression of a human oxytocin receptor

Kimura, Tadashi; Takahashi, Osamu; Mori, Kensaku; Brownstein, Michael J.; Okayama, Hiroto

doi:10.1038/356526a0

Cited by 587 publications

(312 citation statements)

References 25 publications

Supporting

Mentioning

299

Contrasting

Unclassified

Order By: Relevance

“…OXTR mRNAs of different length (3.6 and 4.4 kb) have been also reported. 32 Such kind of variations could be related with the observed association between this region and ASD.…”

Section: Discussionmentioning

confidence: 90%

Association of the oxytocin receptor (OXTR) gene polymorphisms with autism spectrum disorder (ASD) in the Japanese population

et al. 2010

View full text Add to dashboard Cite

The oxytocin receptor (OXTR) gene, which is located on chromosome 3p25.3, has been implicated as a candidate gene for susceptibility of autism spectrum disorder (ASD). Positive associations between OXTR and ASD have been reported in earlier studies. However, the results were inconsistent and demand further studies. In this study, we investigated the associations between OXTR and ASD in a Japanese population by analyzing 11 single-nucleotide polymorphisms (SNPs) using both familybased association test (FBAT) and population-based case-control test. No significant signal was detected in the FBAT test. However, significant differences were observed in allelic frequencies of four SNPs, including rs2254298 between patients and controls. The risk allele of rs2254298 was 'A', which was consistent with the previous study in Chinese, and not with the observations in Caucasian. The difference in the risk allele of this SNP in previous studies might be attributable to an ethnic difference in the linkage disequilibrium structure between the Asians and Caucasians. In addition, haplotype analysis exhibits a significant association between a five-SNP haplotype and ASD, including rs22542898. In conclusion, our study might support that OXTR has a significant role in conferring the risk of ASD in the Japanese population.

show abstract

“…OXTR mRNAs of different length (3.6 and 4.4 kb) have been also reported. 32 Such kind of variations could be related with the observed association between this region and ASD.…”

Section: Discussionmentioning

confidence: 90%

Association of the oxytocin receptor (OXTR) gene polymorphisms with autism spectrum disorder (ASD) in the Japanese population

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Effects of OT in the CNS and in the periphery (e.g., heart and cardiovascular system, kidney, reproductive organs) are critically dependent on presence of OT receptors (OTR) (Gimpl and Fahrenholz, 2001). The OTR is a 389-amino acid polypeptide and belongs to the G-protein coupled receptor superfamily (Gimpl and Fahrenholz, 2001; Kimura et al, 1992). The OTR expressing gene ( OXTR ) is located on chromosomal region 3p25–3p26.2, spans 17 kb, and consists of 3 introns and 4 exons (Gimpl and Fahrenholz, 2001).…”

Section: Ot and Early-life Stress (Els) – Role In Shaping Neural Cmentioning

confidence: 99%

Oxytocin pathways in the intergenerational transmission of maternal early life stress

Toepfer

Heim

Entringer

et al. 2017

Neuroscience & Biobehavioral Reviews

View full text Add to dashboard Cite

Severe stress in early life, such as childhood abuse and neglect, constitutes a major risk factor in the etiology of psychiatric disorders and somatic diseases. Importantly, these long-term effects may impact the next generation. The intergenerational transmission of maternal early life stress (ELS) may occur via pre-and postnatal pathways, such as alterations in maternal-fetal-placental stress physiology, maternal depression during pregnancy and postpartum, as well as impaired mother-offspring interactions. The neuropeptide oxytocin (OT) has gained considerable attention for its role in modulating all of these assumed transmission pathways. Moreover, central and peripheral OT signaling pathways are highly sensitive to environmental exposures and may be compromised by ELS with implications for these putative transmission mechanisms. Together, these data suggest that OT pathways play an important role in the intergenerational transmission of maternal ELS in humans. By integrating recent studies on gene-environment interactions and epigenetic modifications in OT pathway genes, the present review aims to develop a conceptual framework of intergenerational transmission of maternal ELS that emphasizes the role of OT.

show abstract

“…4A(À)). PGF 2a and oxytocin are involved in pregnancy and parturition (Casey & MacDonald 1997;Sugimoto et al 1997), and both receptors are expressed in the ovary (Kimura et al 1992;Sugimoto et al 1994;Ezashi et al 1997), PGF 2a and then oxytocin were added to the hCG-treated granulosa cells. As shown in Fig.…”

Section: Promoter Activity Of 20a-hsd Gene and Three Akr Genesmentioning

confidence: 99%

Close kinship of human 20α‐hydroxysteroid dehydrogenase gene with three aldo‐keto reductase genes

Nishizawa¹,

et al. 2000

View full text Add to dashboard Cite

Background: 20a-Hydroxysteroid dehydrogenase (HSD) is a member of the aldo-keto reductase (AKR) superfamily and catalyses the reaction of progesterone to the inactive form 20a-hydroxyprogesterone. Progesterone plays an important role in the maintenance of pregnancy, and, in rodents, plasma progesterone levels decrease abruptly just before parturition. The induction of 20a-HSD is thought to be responsible for the decrease in plasma progesterone at term. High homology between human 20a-HSD [AKR 1C1] cDNA with other AKRs had caused dif®culty in gene isolation and expression analysis. Thus, the metabolism of progesterone in the human reproductive system remained unclear.

show abstract

Structure and expression of a human oxytocin receptor

Cited by 587 publications

References 25 publications

Association of the oxytocin receptor (OXTR) gene polymorphisms with autism spectrum disorder (ASD) in the Japanese population

Association of the oxytocin receptor (OXTR) gene polymorphisms with autism spectrum disorder (ASD) in the Japanese population

Oxytocin pathways in the intergenerational transmission of maternal early life stress

Close kinship of human 20α‐hydroxysteroid dehydrogenase gene with three aldo‐keto reductase genes

Contact Info

Product

Resources

About