Structure and dynamics of adl-homocysteine functionalized fullerene-C₆₀–gold nanocomposite: a femtomolarl-histidine sensor

Abstract

An Au@Hcys-C60 nanocomposite for l-histidine sensing.

Carbon Nanostructure-based Sensors: A Brief Review on Recent Advances

“…e presence of fully conjugated π-electrons confined in zero dimension leads to a strong redox activity and remarkable electronic properties [16]. Also, FLN-truncated icosahedral structure is an excellent electron acceptor [32]. One of the most significant properties of FLNs is their ability to react with different molecules and functional groups.…”

“…According to the authors, the designed biosensor has great potential to detect ATP at ultralow levels (detection limit of 3.30 fM). Recent works have shown the design of sensors for L-histidine [32], prostate antigen [151], proteins [152,153], biomarkers [154,155], and several others biomolecules [156][157][158][159].…”

“…Besides the improvement in the dispersion for the production of hybrid sensors, functionalization of FLN with appropriate groups can also increase their solubility in water, enhancing their biocompatibility [134,137,138,151]. In addition, the sensitivity towards several molecules [139] can also be improved, as long as the charge recombination in the sensor [32].…”

Amino-Functionalized Ti3C2 MXene Quantum Dots as Photoluminescent Sensors for Diagnosing Histidine in Human Serum

“…25 The terminal amino-N and carboxylate-O donors are the primary ligation sites of these molecules, and they make it possible to coordinate metal atoms. 26,27 There are various methods for detecting His, including capillary electrophoresis, 28 electrochemical detection technologies, 29,30 mass spectrometry, 31 and calorimetric techniques. 32 However, the primary drawbacks of these technologies are the high cost of detection equipment, the time consumption of the sample preparation process, and the absence of a wide detection range and the low detection limit.…”

“…Histidine (His) is one of the necessary basic amino acids in biological bases; it plays a vital role in the growth and tissue repair of humans and animals, and abnormal levels of His are response indicators for many diseases, such as lung cancer, liver failure, rheumatoid arthritis, and Alzheimer’s disease . The terminal amino-N and carboxylate-O donors are the primary ligation sites of these molecules, and they make it possible to coordinate metal atoms. , There are various methods for detecting His, including capillary electrophoresis, electrochemical detection technologies, , mass spectrometry, and calorimetric techniques . However, the primary drawbacks of these technologies are the high cost of detection equipment, the time consumption of the sample preparation process, and the absence of a wide detection range and the low detection limit.…”