“…Starting from the low wavelengths, the peaks in the range 530-600 cm -1 (Figure S3) can be attributed to the Ti-O stretching bond and they are characteristic of the BaTiO3 compound. 40 Shifting to higher wavelengths, the peak at 1450 cm -1 that can be seen in spectrum i ) of plain BTNPs can be attributed to an impurity of BaCO 3 as it has been reported elsewhere. 40 The peaks between 1000-1100 cm -1 (spectrum ii )) are attributed to the C-O-C and C-O-H stretching 41 vibration of the aliphatic chain of poly(ethylene glycol) (PEG), while the peaks in the range 1600-1670 and 1300-1460 cm -1 (spectrum iii )) can be attributed to the Amide I (C=O stretching) 42 and Amide III 40 vibrations of the attached anti-transferrin antibody.…”
Section: Resultssupporting
confidence: 66%
“…40 Shifting to higher wavelengths, the peak at 1450 cm -1 that can be seen in spectrum i ) of plain BTNPs can be attributed to an impurity of BaCO 3 as it has been reported elsewhere. 40 The peaks between 1000-1100 cm -1 (spectrum ii )) are attributed to the C-O-C and C-O-H stretching 41 vibration of the aliphatic chain of poly(ethylene glycol) (PEG), while the peaks in the range 1600-1670 and 1300-1460 cm -1 (spectrum iii )) can be attributed to the Amide I (C=O stretching) 42 and Amide III 40 vibrations of the attached anti-transferrin antibody. The peaks at 2280-2400 and 2850-3000 cm -1 (spectra ii ) and iii )) are attributed to the C-H stretching bond of the DSPE-PEG while the peak at 3320 cm -1 (spectrum iii )) can be attributed both to the O-H stretching vibration of the DSPE-PEG/TfR antibody as well as to the Amide A (N-H stretching) 43 of the TfR antibody.…”
Major obstacles to the successful treatment of gliolastoma multiforme are mostly related to the acquired resistance to chemotherapy drugs and, after surgery, to the cancer recurrence in correspondence of residual microscopic foci. As innovative anticancer approach, low-intensity electric stimulation represents a physical treatment able to reduce multidrug resistance of cancer and to induce remarkable anti-proliferative effects by interfering with Ca2+ and K+ homeostasis and by affecting the organization of the mitotic spindles. However, to preserve the proliferation and behavior of healthy cells, it is utterly important to direct the electric stimuli only to malignant cells. In this work, we propose a nanotechnological approach based on ultrasound-sensitive piezoelectric nanoparticles to remotely deliver electric stimulations to glioblastoma cells. Barium titanate nanoparticles (BTNPs) have been functionalized with an antibody against the transferrin receptor (TfR) in order to obtain the dual targeting of blood-brain barrier and of glioblastoma cells. The remote ultrasound-mediated piezo-stimulation allowed to significantly reduce in vitro the proliferation of glioblastoma cells and, when combined with a sub-toxic concentration of temozolomide, induced an increased sensitivity to the chemotherapy treatment and remarkable anti-proliferative and pro-apoptotic effects.
“…Starting from the low wavelengths, the peaks in the range 530-600 cm -1 (Figure S3) can be attributed to the Ti-O stretching bond and they are characteristic of the BaTiO3 compound. 40 Shifting to higher wavelengths, the peak at 1450 cm -1 that can be seen in spectrum i ) of plain BTNPs can be attributed to an impurity of BaCO 3 as it has been reported elsewhere. 40 The peaks between 1000-1100 cm -1 (spectrum ii )) are attributed to the C-O-C and C-O-H stretching 41 vibration of the aliphatic chain of poly(ethylene glycol) (PEG), while the peaks in the range 1600-1670 and 1300-1460 cm -1 (spectrum iii )) can be attributed to the Amide I (C=O stretching) 42 and Amide III 40 vibrations of the attached anti-transferrin antibody.…”
Section: Resultssupporting
confidence: 66%
“…40 Shifting to higher wavelengths, the peak at 1450 cm -1 that can be seen in spectrum i ) of plain BTNPs can be attributed to an impurity of BaCO 3 as it has been reported elsewhere. 40 The peaks between 1000-1100 cm -1 (spectrum ii )) are attributed to the C-O-C and C-O-H stretching 41 vibration of the aliphatic chain of poly(ethylene glycol) (PEG), while the peaks in the range 1600-1670 and 1300-1460 cm -1 (spectrum iii )) can be attributed to the Amide I (C=O stretching) 42 and Amide III 40 vibrations of the attached anti-transferrin antibody. The peaks at 2280-2400 and 2850-3000 cm -1 (spectra ii ) and iii )) are attributed to the C-H stretching bond of the DSPE-PEG while the peak at 3320 cm -1 (spectrum iii )) can be attributed both to the O-H stretching vibration of the DSPE-PEG/TfR antibody as well as to the Amide A (N-H stretching) 43 of the TfR antibody.…”
Major obstacles to the successful treatment of gliolastoma multiforme are mostly related to the acquired resistance to chemotherapy drugs and, after surgery, to the cancer recurrence in correspondence of residual microscopic foci. As innovative anticancer approach, low-intensity electric stimulation represents a physical treatment able to reduce multidrug resistance of cancer and to induce remarkable anti-proliferative effects by interfering with Ca2+ and K+ homeostasis and by affecting the organization of the mitotic spindles. However, to preserve the proliferation and behavior of healthy cells, it is utterly important to direct the electric stimuli only to malignant cells. In this work, we propose a nanotechnological approach based on ultrasound-sensitive piezoelectric nanoparticles to remotely deliver electric stimulations to glioblastoma cells. Barium titanate nanoparticles (BTNPs) have been functionalized with an antibody against the transferrin receptor (TfR) in order to obtain the dual targeting of blood-brain barrier and of glioblastoma cells. The remote ultrasound-mediated piezo-stimulation allowed to significantly reduce in vitro the proliferation of glioblastoma cells and, when combined with a sub-toxic concentration of temozolomide, induced an increased sensitivity to the chemotherapy treatment and remarkable anti-proliferative and pro-apoptotic effects.
“…With the development of science and technology, more and more preparation methods have been innovated [56–61] to better the properties of BT nanoparticles and broaden their applications; therefore, the continuous improvement for their preparation technologies will result in a broader development prospect, predictably.…”
“…Из химически чистых (reagent) реактивов были получены наночастицы BTО в тетрагональной и кубической фазах с формой близкой к сферической методом пероксидного синтеза [10][11][12]. Стабилизация наночастиц достигалась обогащением их поверхности гидроксильными группами −OH − путем кипячения (423 K) в 30% растворе H 2 O 2 в течение 3 h. Полученные гидроксилированные наночастицы дополнительно модифицировались молекулами олеата натрия C 17 H 33 COONa (с гидрофобной (C 17 H 33 ) и гидрофильной (COONa) частями) в процессе интенсивного перемешивания при температуре 358 K в течение 4 h в 0.5% водном растворе согласно [11,12]. Гомогенность коллоидных систем ВТO, используемых при осаждении пленки Ленгмюра-Блоджетт (ЛБ), повышалась в центрифуге MiniSpin plus, Eppendorf с ускорением 14 000g.…”
Section: результаты и обсуждениеunclassified
“…9). При комнатной температуре обнаружены рефлексы тетрагональной (сегнетоэлектрической) (C 1 v ) фазы, а также метастабильной кубической фазы (O 1 h ), как остаточной после пероксидного синтеза [12]. Результаты рентгенофазового анализа согласуются с представленными выше данными электронографического анализа (рис.…”
With the use of the Langmuir-Blodgett (LB) method on the KSV NIMA 2002 plant, ferro-electric films of the stabilized barium titanate (ST BTO) from colloidal system of sodium oleate aqueous solution have been produced, which were studied with small angle X-ray scattering and dynamic light scattering techniques. Coagulants with the most characteristic hydrodynamic diameter ~ 200 nm are found and the physical model of their formation from barium titanate nanoparticles (~ 20 nm) in this colloidal system is proposed.
By means of compression-expansion isotherms with the use of a MicroBAM micro-scope and the device for measurement of surface potential SPOT, optimum parameters of sedimentation are determined, which made it possible to produce uniform ferroelectric films with ST BTO particles of ~ 20 nm in size and a forbidden band width of 3.6 eV.
With scanning probe and electron microscopy, vibrational and X-ray photoelectron spectroscopy, and also X-ray diffractometry, topological and structural features and distri-bution of chemical elements in the produced films on different substrates have been stud-ied.
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