Structure and cytotoxicity of steroidal glycosides from Allium schoenoprasum

Timité, Gaoussou; Mitaine-Offer, Anne Claire; Miyamoto, Tomofumi; Tanaka, Chiaki; Mirjolet, Jean François; Duchamp, Olivier; Lacaille‐Dubois, Marie‐Aleth

doi:10.1016/j.phytochem.2012.12.001

Cited by 40 publications

(17 citation statements)

References 15 publications

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“…Comparison of the activity exhibited by both compounds in term of chemical structure confirmed that hydroxylation at C-6 has a negative effect on the cytotoxic activity. This in agreement with previous findings [19,20] where the negative effect of oxygenation at C-6, due to hydroxyl group [19] or keto group [20], has been found on analogous compounds.…”

Section: Resultssupporting

confidence: 94%

3-Keto umbilicagenin A and B, new sapogenins from Allium umbilicatum Boiss

et al. 2015

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Section: Resultssupporting

confidence: 94%

3-Keto umbilicagenin A and B, new sapogenins from Allium umbilicatum Boiss

et al. 2015

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“…Anticarcinogenic activity was shown by a variety of steroidal saponins from different plants including Digitalis trojana (Kirmizibekmez et al 2014), Allium schoenoprasum (Timité et al 2013), Dioscorea zingiberensis (Tong et al 2012), Fagonia indica (Waheed et al 2012), Rhizoma Paridis (Xiao et al 2012), Solanum violaceum (Yen et al 2012), Agave sisalana (Chen et al 2011a, b), Anemarrhena asphodeloides (Kang et al 2011), Dioscorea bulbifera , Trigonella foenum-graecum (Kawabata et al 2011), Paris polyphylla (Zhu et al 2011), Raphia farinifera (Tapondjou et al 2015) etc.…”

Section: The Value Of Steroidal Saponinsmentioning

confidence: 99%

Recent advances in steroidal saponins biosynthesis and in vitro production

Upadhyay

Jeena

Shikha

et al. 2018

Planta

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Main conclusion Steroidal saponins exhibited numerous pharmacological activities due to the modification of their backbone by different cytochrome P450s (P450) and UDP glycosyltransferases (UGTs). Plant-derived steroidal saponins are not sufficient for utilizing them for commercial purpose so in vitro production of saponin by tissue culture, root culture, embryo culture, etc, is necessary for its large-scale production.Saponin glycosides are the important class of plant secondary metabolites, which consists of either steroidal or terpenoidal backbone. Due to the existence of a wide range of medicinal properties, saponin glycosides are pharmacologically very important. This review is focused on important medicinal properties of steroidal saponin, its occurrence, and biosynthesis. In addition to this, some recently identified plants containing steroidal saponins in different parts were summarized. The high throughput transcriptome sequencing approach elaborates our understanding related to the secondary metabolic pathway and its regulation even in the absence of adequate genomic information of non-model plants. The aim of this review is to encapsulate the information related to applications of steroidal saponin and its biosynthetic enzymes specially P450s and UGTs that are involved at later stage modifications of saponin backbone. Lastly, we discussed the in vitro production of steroidal saponin as the plant-based production of saponin is time-consuming and yield a limited amount of saponins. A large amount of plant material has been used to increase the production of steroidal saponin by employing in vitro culture technique, which has received a lot of attention in past two decades and provides a way to conserve medicinal plants as well as to escape them for being endangered.

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“…4) linkage between glucose and rhamnose. The evaluation of chemical shifts and spin-spin couplings of two anomeric protons allowed the identification of one b-glucopyranose and one a-rhamnopyranose [2]. The absolute configuration of glucose was determined as D and that of rhamnose as L, as described above.…”

Section: Resultsmentioning

confidence: 99%

“…Plants of the genus Allium (Liliaceae), well known for their culinary uses, contain abundant sulfur compounds [1] and steroidal saponins [2][3][4]. Chinese chive (Allium tuberosum) grows naturally in central and northern parts of Asia and is cultured in China, Japan, Korea, India, Nepal, Thailand, and Philippines.…”

Section: Introductionmentioning

confidence: 99%