Structure and conformational analysis of 5,11-dibenzyldibenzo[b,f][1,5]diazocine-6,12-dione. A novel approach for new chemosensitizers

Theoretical study of some verapamil derivatives

“…The results reflect the differences between the two selected conformers, as well as between the dithiane and the dithianetetraoxide derivatives. The folded conformers, A, are predicted to be more stable than B, in agreement with the theoretical data of Nonnenmacher et al 30 obtained by molecular mechanics, using TRIPOS force fields for verapamil and a new chemosensitizer compound 5,11‐dibenzyldibenzo[ b,f ]1,5 diazocine‐6,12‐dione. The solvation free energy differences in octanol and water, respectively, noted as Δ(Δ G sol ), are significantly larger for the dithiane derivatives as compared with the corresponding tetraoxides.…”

Quinolines Formation by Condensation of Heteroaromatic Ketones and 2‐Aminobenzophenones under MW Irradiation

“…Dibenzo[b,f][1,5]diazocine products are understood to be formed by the self‐condensation of 2‐aminobenzophenones (Scheme ). Dibenzo[b,f][1,5]diazocines have drawn the attention of organic chemists since the 1960s due to antiviral, cholesterol‐lowering and hormone‐like activity . Moreover, their reversible conformational changes during electrochemical redox processes make them interesting building blocks for molecular machines and artificial muscles .…”

Simple synthesis of quinolines and dibenzo[b,f][1,5]diazocines under microwave irradiation

“…These compounds are structurally similar to calcium channel antagonist such as diltiazem, which has been successfully tested as a chemosensitizer against multiple drug resistance (MDR). 6 We first carried out Friedlander 7,8 condensation of various heteroaromatic ketones 2a-i with 2-aminobenzophenones 1a-b under MW irradiation. To explore the scope and limitations of this condensation reaction under the above-mentioned reaction conditions, we generated a mini-library of quinolines.…”