Structure and chemotherapeutical activity of a polyisoprenylated benzophenone from the stem bark of Garcinia huillensis

Antibacterial activity of the extracts from the fruit rinds of Garcinia cowa and Garcinia pedunculata against food borne pathogens and spoilage bacteria

“…Small and complex molecules have been isolated from different parts of the various species of Garcinia, which include xanthones and their derivatives (Bennet & Lee, 1989;Rama Rao, Venkataswamy, & Yemul, 1980) exhibiting a wide range of biological and pharmacological activities such as antimicrobial, antioxidant, antitumour-promoting, cytotoxic, etc. (Adegoke, Kumar, Sambaiah, & Lokesh, 1998;Asano, Chiba, Tada, & Yoshii, 1996;Bakana et al, 1987;Iinuma, Tosa, Tanaka, Kanamaru, et al, 1996;Mackeen et al, 2000;Minami et al, 1994;Minami, Kuwayama, Yoshizawa, & Fukuyama, 1996;Minami et al, 1995). Crude extracts as well as partially purified compounds from different parts of some species of Garcinia plants have shown potential antibacterial activities.…”

“…Crude extracts as well as partially purified compounds from different parts of some species of Garcinia plants have shown potential antibacterial activities. A polyisoprenylated benzophenone known as garcinol isolated from stem bark of G. huillensis has been shown to possess chemotherapeutical activity against Gram-positive and Gramnegative cocci but was inactive against Gram-negative enteric bacilli (Bakana et al, 1987). Alpha-mangostin, rubraxanthone and xanthochymol isolated from G. mangostana, G. diocia and G. subelliptica, respectively, showed strong antibacterial activity against both methicillin-resistant and methicillinsensitive Staphylococcus aureus Iinuma, Tosa, Tanaka, Kanamaru, et al, 1996).…”

The chemistry and medicinal uses of the underutilized Indian fruit tree Garcinia indica Choisy (kokum): A review

“…However garcinol is reported to be ineffective on gram-negative enteric bacilli (Bakana et al, 1987). The kokum leaf extract also possesses antibacterial effect against the pathogenic Salmonella typhi, Salmonella paratyphi A, and Salmonella typhimurium (Pasha, Sayeed, Ali, & Khan, 2009).…”

“…5. Garcinol effective alone and in combination with clarithromycin on the H. pylori (Sang et al, 2001;Sang et al, 2002) but is ineffective on gram-negative enteric bacilli (Bakana et al, 1987). Antifungal activity 1.…”

Microwave‐assisted synthesis of 2‐amino and 2‐azetidinonyl 5‐(2‐benzoyl‐phenoxymethyl) 1,3,4‐oxadiazoles

“…These compounds also showed antianaphylactic [2] and antiinflammatory activity [2,3]. Bakana et al [4] isolated a benzophenone analogue (garcinol) from the stem bark of Garcinia huillensis grown in Zaire and used in central-African traditional medicine, and found this to exhibit chemotherapeutical activity against grampositive and gram-negative cocci, mycobacteria, and fungi [4]. 1,3,4-Oxadiazole is associated with potent pharmacological activity due to the presence of toxophoric N C O linkage [5].…”