Structure and Biosynthesis of Hectoramide B, a Linear Depsipeptide from the Marine CyanobacteriumMoorena producensJHB Discovered via Co-culture withCandida albicans
Abstract:The tropical marine cyanobacterium Moorena producens JHB is a prolific source of secondary metabolites with potential biomedical utility. Previous studies of this strain led to the discovery of several novel compounds such as the hectochlorins and jamaicamides; however, bioinformatic analyses of its genome suggested that there were many more cryptic biosynthetic gene clusters yet to be characterized. To potentially stimulate the production of novel compounds from this strain, it was co-cultured with Candida al… Show more
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