Structure and biological activity of particles produced from highly activated carbon adsorbent

Sarnatskaya, V. V.; Shlapa, Yuliia; Lykhova, Aleksandra; Brieieva, O V; Prokopenko, I. V.; Sidorenko, Alexey; Solopan, Sergii; Kolesnik, D L; Belous, A. G.; Николаев, В. Г.

doi:10.1016/j.heliyon.2022.e09163

Cited by 4 publications

(2 citation statements)

References 30 publications

(28 reference statements)

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“…A recent publication reveals another interesting way of albumin conformation restoration with the help of carbon particles (CPs) derived from AC. These CPs have a low-binding affinity to albumin and purify albumin molecules from the trace concentrations of strongly bound ligands [155].…”

Section: Serum Albuminmentioning

confidence: 99%

Activated Carbon for Sepsis Prevention and Intervention: A Modern Way of Utilizing Old Therapies

Snezhkova

Redl

Grillari

et al. 2023

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(1) Background: Uncontrolled inflammation often contributes to life-threatening sepsis sequela such as multi-organ dysfunction syndrome (MODS), and is accompanied by abnormal levels of pathological and damage-associated molecular patterns (PAMPs & DAMPs) in biological fluids. Activated carbon or charcoal (AC) of new generation with ameliorated biocompatibility has spurred renewed interest in the regulation of these toxins’ levels in inflammation states. (2) Methods: We searched PubMed, Google Scholar, ScienceDirect, Researchgate, and other sources for the relevant literature from 1550 B.C. till 2022 A.C. (3) Results: Laboratory and clinical investigations demonstrate that activated carbon or charcoal (AC) mitigates inflammation in different pathological states when applied orally, per rectum, or in a hemoperfusion system. AC protects the microbiome and bone marrow, acts as an anti-inflammatory and anti-oxidant remedy, and recovers the plasmatic albumin structure. The mechanism of AC action is related to a non-selective (broad-range) or/and selective adsorption of PAMPs & DAMPs from biological fluids. A high-adsorptive capacity towards noxious substances and application of AC as early as possible seems paramount in inflammation treatment for preventing sepsis and/or multi-organ failure. (4) Conclusion: AC could be considered an adjunctive treatment for preventing sepsis and/or multi-organ failure.

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Section: Serum Albuminmentioning

confidence: 99%

Activated Carbon for Sepsis Prevention and Intervention: A Modern Way of Utilizing Old Therapies

Snezhkova

Redl

Grillari

et al. 2023

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“…It is known from literary sources that AUT-M is one doi: https://doi.org/10.15407/ubj95.06.064 of the enterosorbents with high adsorption action. This sorbent is a macroporous preparation, consists of carbon fibers and has a specific pore surface area of about 2000-2500 m 2 /g [8][9][10][11].…”

mentioning

confidence: 99%

AUT-M enterosorbent stabilizes glutathione system in vincristine-treated rats with dimethylhydrazine-induced colon cancer

Kachur,

Fira,

Lykhatskyі

et al. 2023

Ukr.Biochem.J.

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Colorectal cancer is one of the leading causes of mortality in the world. The search for new methods of therapy for this disease that could correct the state of oxidative stress during the development of neoplasms is up to date. The aim of this work was to study the level of reduced glutathione and the activity of glutathione-dependent enzymes in the development of 1,2 dimethylhydrazine-induced colon cancer in rats while treated with vincristine and the use of enterosorbent. To induce carcinogenesis, dimethylhydrazine was administered to male rats subcutaneously for 30 weeks at a dose of 7.2 mg/kg of body weight. The rats with induced colon cancer received entorosorbent per os at a dose of 0.2 g per 100 g of body weight daily for 21 days. After detoxification therapy, the rats were administered cytostatic vincristine daily at a dose of 0.23 mg/kg for 14 days. A decrease in the content of reduced glutathione, the activity of glutathione reductase and glutathione peroxidase in the blood and liver tissue of rats with colorectal cancer was established. The use of enterosorbent AUT-M was shown to be effective in stabilizing the indicators of the glutathione system in rats with induced colon cancer. Cytostatic vincristine did not significantly affect the change of the studied indicators, confirming the effectiveness of previous sorption measures. Keywords: blood, colorectal cancer, entorosorbent, glutathione, glutathione peroxidase, glutathione reductase, liver, vincristine

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Cellulose, graphene and graphene-cellulose composite aerogels and their application in water treatment: a review

Sekwele,

Tichapondwa,

Mhike

2024

Discov Mater

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Due to their unique properties such as outstanding specific surface areas, aerogels can potentially offer a cost-effective and efficient water and wastewater treatment solution thereby solving the worldwide ever-growing water pollution conundrum. This review explores the developments and progress in the application of cellulose, graphene, and cellulose-graphene composite aerogels in addressing water treatment challenges. The objective of this study was to critically review the state-of-the-art with respect to synthesis methods and properties of cellulose, graphene, and cellulose-graphene composite aerogels and their application, effectiveness and performance in water and wastewater treatment. It is evident from the review that cost-effective aerogel production methods that can be scaled up easily still need to be developed to enable commercial viability of aerogels in water treatment. Furthermore, the mechanical properties of aerogels, particularly stiffness and strength, are a hinderance to expanding their utility. The potential for functionalization of the aerogels through fabrication of aerogel nanocomposites or incorporation of functional groups was recognized as a viable method to enhance their properties and effectiveness in water treatment and other advanced industrial-scale applications. Graphene-cellulose composite aerogels have enhanced properties, removal capacities and efficiencies for pollutants from water compared to aerogels prepared from the individual materials. The regeneration ability and reusability of the composite aerogels make them an attractive option for practical applications. Although the potential of cellulose, graphene, and cellulose-graphene composite aerogels in water treatment applications is apparent, the impact of their production, utilization and subsequent disposal on sustainability and the environmental is yet to be fully studied.

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Structure and biological activity of particles produced from highly activated carbon adsorbent

Cited by 4 publications

References 30 publications

Activated Carbon for Sepsis Prevention and Intervention: A Modern Way of Utilizing Old Therapies

Activated Carbon for Sepsis Prevention and Intervention: A Modern Way of Utilizing Old Therapies

AUT-M enterosorbent stabilizes glutathione system in vincristine-treated rats with dimethylhydrazine-induced colon cancer

Cellulose, graphene and graphene-cellulose composite aerogels and their application in water treatment: a review

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