Structure and Biological Activity of Plant Growth Regulators Produced by<i>Penicillium</i>sp. No. 31f

Kimura, Yasuo; Shiojima, Kenichi; Nakajima, Hiromitsu; Hamasaki, Takashi

doi:10.1271/bbb.56.1138

Cited by 13 publications

(11 citation statements)

References 2 publications

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“…Compound 20 was identified as 2,5-dimethyl-7-hydroxychromone by comparison with data in reference [25]. Compound 21 was identified as 7-hydroxy-2-hydroxymethyl-5-methyl-4 H -chromen-4-one by comparison with data in reference [26]. Compound 22 was identified as β-adenosine by comparison with data in reference [27].…”

Section: Resultsmentioning

confidence: 99%

Inhibitors of BRD4 Protein from a Marine-Derived Fungus Alternaria sp. NH-F6

Zhang

Zhou

2017

Marine Drugs

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Bromodomains (BRD) are readers of the epigenetic code that regulate gene transcription through their recognition of acetyl-lysine modified histone tails. Recently, bromodomain-containing proteins such as BRD4 have been demonstrated to be druggable through the discovery of potent inhibitors. These protein–protein interaction inhibitors have the potential to modulate multiple diseases by their profound anti-inflammatory and antiproliferative effects. In order to explore new BRD4 inhibitors as well as lead compounds for the development of new drugs, the secondary metabolites of Alternaria sp. NH-F6, a fungus isolated from deep-sea sediment samples, were analyzed systematically. Five new compounds including two new perylenequinones (1–2), one new alternaric acid (3), 2-(N-vinylacetamide)-4-hydroxymethyl-3-ene-butyrolactone (4), one new cerebroside (5), together with 19 known compounds (6–24) were isolated from the ethyl acetate extracts of this strain. Their structures were elucidated using nuclear magnetic resonance (NMR) and high resolution electrospray ionization mass spectrometry (HR-ESI-MS) analyses. Finally, all these compounds were evaluated for their inhibitory activity against BRD4 protein, and compound 2 exhibited a potent inhibition rate of 88.1% at a concentration of 10 µM. This research provides a new BRD4 inhibitor which may possess potential antitumoral, antiviral, or anti-inflammatory pharmaceutical values.

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Section: Resultsmentioning

confidence: 99%

Inhibitors of BRD4 Protein from a Marine-Derived Fungus Alternaria sp. NH-F6

Zhang

Zhou

2017

Marine Drugs

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“…It was concluded that more griseofulvin was produced by Penicillium griseofulvum in the presence of glucose than other sugars [21]. Kimura et al, [22] have studied the production of griseofulvin by a soil isolate of Penicillium species using malt extract medium at 24°C for 23 days. Griseofulvin and dechlorogriseofulvin were extracted using ethyl acetate as solvent.…”

Section: Lab Scale Productionmentioning

confidence: 99%

“…Griseofulvin and dechlorogriseofulvin were extracted using ethyl acetate as solvent. After evaporation of the solvent under vacuum, the extract is subjected to silica gel column chromatography and eluted stepwise with n-hexane-acetone [22]. Griseofulvin was isolated along with dechlorogriseofulvin from fermentation broth of Penicillium griseofulvum and some of these Penicillium janczewskii.…”

Section: Lab Scale Productionmentioning

confidence: 99%

Studies on production of griseofulvin

Dasu

Panda

1999

Bioprocess Engineering

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Griseofulvin is an antifungal antibiotic and is used for the treatment of mycotic diseases of human, veterinary and plant systems. It is synthesised by many species of Penicillium. The exploitation of fermentation process plays a vital role in the industrial applications. This leads to techno-economic feasibility of the processes. The present review mainly discusses on the production of griseofulvin in soil, in plants and by various micro-organisms. This communication also summarises the various factors which in¯uence the griseofulvin production and strain improvement by mutation for enhanced production.

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“…In the course of the search for new plant growth regulators among fungal metabolitcs, Kimura et al (1992b) succeeded in isolating new metabolites promoting the growth of roots and stems. One of the interesting new metabolites produced by Penicillium sp.…”

Section: Other New Fungal Compounds With Plant Honnone-like Effectsmentioning

confidence: 99%

“…produces two growth regulators of the chromone type, the altechromones 5-hydroxy-2,7-dimethyl chromone and 2-acetonyl-5-hydroxy-7-methyl chromone. Both metabolites promote root growth of lettuce seedlings by about 50% at a concentration of 3mgl-1 and 100mgl-1 , respectively (Kimura 1992b). Kimura et al (1990) also isolated a new root promoting substance from the culture fluid of the fungus Sesquicillium candelabrum, which was named sescandelin (Fig.…”

Section: Other New Fungal Compounds With Plant Honnone-like Effectsmentioning

confidence: 99%

Fungal Phytohormones in Pathogenic and Mutualistic Associations

Tudzynski

1997

Plant Relationships

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Structure and Biological Activity of Plant Growth Regulators Produced byPenicilliumsp. No. 31f

Cited by 13 publications

References 2 publications

Inhibitors of BRD4 Protein from a Marine-Derived Fungus Alternaria sp. NH-F6

Inhibitors of BRD4 Protein from a Marine-Derived Fungus Alternaria sp. NH-F6

Studies on production of griseofulvin

Fungal Phytohormones in Pathogenic and Mutualistic Associations

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