Structure and bioactivity of the polysaccharides in medicinal plant Dendrobium huoshanense

Hsieh, Yves S. Y.; Chien, Chih Cheng; Liao, Sylvian K.S.; Liao, Shih Fen; Hung, Wei Ting; Yang, Wen Bin; Lin, Chih-Chien; Cheng, Ting-Jen Rachel; Chang, Chia Chuan; Fang, Jim‐Min; Wong, Chi Huey

doi:10.1016/j.bmc.2008.04.042

Cited by 153 publications

(98 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Erianin, a low molecular-weight product isolated from Dendrobium chrysotoxum, has been shown to have anti-angiogenic activity in vitro and in vivo (17). Exploration ofthe effects ofthe polysaccharides derived from Dendrobium has also shown that they have immunomodulatory properties (10)(11)(12). The polysaccharides, especially the stem mucilage, significantly induced an increase in production of IFN-y, IL-lO, IL-6, and IL-lu in murine splenocytes.…”

Section: Resultsmentioning

confidence: 99%

A Pilot Study Evaluating the Clinical and Immunomodulatory Effects of an Orally Administered Extract ofDendrobium Huoshanensein Children with Moderate to Severe Recalcitrant Atopic Dermatitis

et al. 2011

Int J Immunopathol Pharmacol

View full text Add to dashboard Cite

Atopic dermatitis (AD) is a common inflammatory skin disorder for which few safe and effective systemic treatments are available. To test the clinical and immunomodulatory effects of a crude polysaccharide fraction isolated from Dendrobium huoshanense for the treatment of AD, we conducted a pilot, uncontrolled case series study. Twenty-seven patients aged 4-18 years (mean±SD, 10.82±4.4) with AD that had not responded to topical therapy were treated with polysaccharide derived from D. huoshanense for 4 weeks and followed-up for another 4 weeks. Progression of AD was determined with the Lund-Browder chart for children, the Investigator's Global Atopic Dermatitis Assessment (IGADA), and the Scoring Atopic Dermatitis (SCORAD) at weeks 0, 2, 4, and 8. Serum levels of cytokines were evaluated. Safety was determined with laboratory and clinical tests. The lesion area, IGADA score, total SCORAD result, and score for sleeplessness decreased significantly from weeks 0 to 4, but did not change significantly between weeks 4 and 8. The scores for subjective symptoms and pruritus decreased significantly from week 0 to week 4 and increased significantly from week 4 to week 8. Serum levels of IL-S, IL-13, IFN-y, and TGF-p1 decreased significantly between weeks 0 and 4 and between weeks 0 and 8. No significant difference in the levels of IL-10 was found. The polysaccharide from D. huoshanense reduced the levels of some cytokines associated with AD and had beneficial effects on symptoms. No serious adverse effects occurred when it was administered orally for 4 weeks.Atopic dermatitis (AD) is a common inflammatory skin disorder that afflicts from 10%

show abstract

Section: Resultsmentioning

confidence: 99%

A Pilot Study Evaluating the Clinical and Immunomodulatory Effects of an Orally Administered Extract ofDendrobium Huoshanensein Children with Moderate to Severe Recalcitrant Atopic Dermatitis

et al. 2011

Int J Immunopathol Pharmacol

View full text Add to dashboard Cite

show abstract

“…Among the Dendrobium genus, most studies have focused on the bioactivity and structural types of some small molecules, such as bibenzyl, phenanthrene, anthracene, fluorene, coumarin, flavone, cinnamate, sesquiterpene, sterol, fatty acid, and alkaloids [2][3][4][5][6][7][8][9][10][11][12]. However, the polysaccharide constituents were much less investigated.…”

Section: Introductionmentioning

confidence: 99%

“…There are many published reports that have demonstrated polysaccharide has beneficial activities in antioxidant, immune stimulating and antitumor activities [14][15][16][17]. Polysaccharides from some Dendrobium species have been studied, such as Dendrobium huoshanense [2] and Dendrobium chrysotoxum Lindl. [14].…”

Section: Introductionmentioning

confidence: 99%

In vitro antioxidant activities of a water-soluble polysaccharide derived from Dendrobium nobile Lindl. extracts

Luo

Zhou

et al. 2009

International Journal of Biological Macromolecules

119

View full text Add to dashboard Cite

“…All species in the genus contain polysaccharides, which are thought to be among the major active ingredients of D. officinale for enhancing immunity. The polysaccharides in some other medicinal plants in the genus also have immunomodulative effects [4][5][6]. In a previous study, D. officinale and its closely related species, such as Dendrobium aphyllum and Dendrobium crystallinum, could not be separated solely by their polysaccharide content and monosaccharide composition [7].…”

mentioning

confidence: 99%

Discrimination of the rare medicinal plant Dendrobium officinale based on naringenin, bibenzyl, and polysaccharides

Chen

Wang

et al. 2012

Sci. China Life Sci.

View full text Add to dashboard Cite

The aim of this study was to establish a method for discriminating Dendrobium officinale from four of its close relatives Dendrobium chrysanthum, Dendrobium crystallinum, Dendrobium aphyllum and Dendrobium devonianum based on chemical composition analysis. We analyzed 62 samples of 24 Dendrobium species. High performance liquid chromatography analysis confirmed that the four low molecular weight compounds 4′,5,7-trihydroxyflavanone (naringenin), 3,4-dihydroxy-4′,5-dimethoxybibenzyl (DDB-2), 3′,4-dihydroxy-3,5′-dimethoxybibenzyl (gigantol), and 4,4′-dihydroxy-3,3′,5-trimethoxybibenzyl (moscatilin), were common in the genus. The phenol-sulfuric acid method was used to quantify polysaccharides, and the monosaccharide composition of the polysaccharides was determined by gas chromatography. Stepwise discriminant analysis was used to differentiate among the five closely related species based on the chemical composition analysis. This proved to be a simple and accurate approach for discriminating among these species. The results also showed that the polysaccharide content, the amounts of the four low molecular weight compounds, and the mannose to glucose ratio, were important factors for species discriminant. Therefore, we propose that a chemical analysis based on quantification of naringenin, bibenzyl, and polysaccharides is effective for identifying D. officinale. Dendrobium officinale, naringenin, bibenzyl, polysaccharide, discriminant analysis Citation:Chen X M, Wang F F, Wang Y Q, et al. Discrimination of the rare medicinal plant Dendrobium officinale based on naringenin, bibenzyl, and polysaccharides.

show abstract

Structure and bioactivity of the polysaccharides in medicinal plant Dendrobium huoshanense

Cited by 153 publications

References 44 publications

A Pilot Study Evaluating the Clinical and Immunomodulatory Effects of an Orally Administered Extract ofDendrobium Huoshanensein Children with Moderate to Severe Recalcitrant Atopic Dermatitis

A Pilot Study Evaluating the Clinical and Immunomodulatory Effects of an Orally Administered Extract ofDendrobium Huoshanensein Children with Moderate to Severe Recalcitrant Atopic Dermatitis

In vitro antioxidant activities of a water-soluble polysaccharide derived from Dendrobium nobile Lindl. extracts

Discrimination of the rare medicinal plant Dendrobium officinale based on naringenin, bibenzyl, and polysaccharides

Contact Info

Product

Resources

About