Structure and antitumour activity of fucoidan isolated from sporophyll of Korean brown seaweed Undaria pinnatifida

Synytsya, Andriy; Kim, Woo-Jung; Kim, Sung-Min; Pohl, Radek; Synytsya, Alla; Kvasnička, František; Čopı́ková, Jana; Park, Yong Il

doi:10.1016/j.carbpol.2010.01.052

Cited by 393 publications

(179 citation statements)

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“…Our data showed that the water-soluble extracts isolated from M. pyrifera and U. pinnatifida have different relation fucose/galactose. This relation corresponds with fucoidan content which was higher in U. pinnatifida and the values were similar to those reported in previous studies (Synytsya et al, 2010;Hemmingson et al, 2006). The kinetic of the DPPH reaction of polysacharides extract showed that the highest activity was determined in U. pinnatifida.…”

Section: Discussionsupporting

confidence: 90%

“…Band at 960 cm -1 was related to stretching vibrations with contributions from deformation vibrations of the uronic acids residues in heteropolymeric blocks (Leal et al, 2008). The signal at 625 and 580 cm -1 was attributed to the asymmetric and symmetric O=S=O deformation of sulfates (Sekkal & Legrand, 1993) and the presence of sulfated was confirmed by infrared spectra in both water-soluble extracts due to the characteristic absorption band at 1230 cm -1 (Nikonenko et al, 2000;Synytsya et al, 2010). These polysaccharides usually contain large proportions of L-fucose and sulfate, together with minor amounts of other sugars like xylose, galactose, mannose and glucuronic acid (Ponce et al, 2003).…”

Section: Discussionmentioning

confidence: 83%

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Free radical scavenging activity of extracts from seaweeds Macrocystis pyrifera and Undaria pinnatifida: applications as functional food in the diet of prawn Artemesia longinaris

Díaz

Espino²,

Arzoz³

et al. 2017

lajar

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ABSTRACT. Water-soluble extracts from seaweeds Macrocystis pyrifera (M) and Undaria pinnatifida (U) were prepared to use the polysaccharide bioactive fraction as functional food. Chemical analysis showed that the main components of both extracts were mannitol and fucoidans. Also in both cases minor amounts of rhamnose, glucose, xylose and arabinose were determine. Content of fucose+galactose was higher in U. pinnatifida (8.7%) than in M. pyrifera (5.9%). Extracts were used as feed additive to Artemesia longinaris at inclusion levels of 1 and 2% (M1 and M2; U1 and U2), a diet without extract was used as control. Radical scavenging activities were estimated for two extracts and for midgut gland samples of experimental animals. Scavenging activity was detected in both extracts, the signal decayed to 50 and 62% in 18 min for U. pinnatifida and M. pyrifera, respectively. After 30 days of feeding, results did not show variation of survival, but growth was improved in animals fed with U1 and U2. Supplementation with 1 and 2% of U. pinnatifida showed similar quenching capacity of homogenates than those fed with M2 with a rapid 1,1-diphenylpicrylhydrazyl (DPPH) decay at 2 min of reaction. Recommended concentration for culture A. longinaris is 2%, as it is that produce the best antioxidant capacity, although the growth performance was improved also significantly only with U. pinnatifida extract.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 83%

Free radical scavenging activity of extracts from seaweeds Macrocystis pyrifera and Undaria pinnatifida: applications as functional food in the diet of prawn Artemesia longinaris

Díaz

Espino²,

Arzoz³

et al. 2017

lajar

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“…또한 특정 해조류에서는 항 암, 저혈당증, 항바이러스, 혈관신생억제, 항산화, 항염증 등에 효과가 확인되어 (Duan et al 2006;Heo et al 2005;Kang et al 2011;Koyanagi et al 2003;Kuda et al 2005;Lamela et al 1989;Lim et al 2002;Synytsya et al 2010;Witvrouw and Clercq 1997 Table 1과 같다. 탄수화물 함량이 약 40%로 가장 높았으며 회분 …”

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Antioxidant Effect of Tropical Seaweed Pylaiella littoralis Extracts Collected from Chuuk Lagoon in Federated States of Micronesia

Ye¹,

Jang²,

Kwon³

et al. 2012

Ocean and Polar Research

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: Pylaiella littoralis was collected in the Chuuk lagoon of the Federated States of Micronesia (FSM). The FSM has a variety of coral reef ecosystems, which provide essential materials, such as minerals, vitamins, essential amino acids, for marine organisms. In this study, the antioxidant activities of ethanol and enzymatic extracts of P. littoralis were evaluated by measuring their scavenging activities on DPPH free radical, Alkyl radical, hydroxyl radical and cell viability. The enzymatic extracts were hydrolyzed to prepare water soluble extracts by using five carbohydrate degrading enzymes (AMG, Celluclast, Termamyl, Ultraflo, and Viscozyme) and five proteases (Alcalase, Flavourzyme, Kojizyme, Neutrase, and Protamex). As a result, the enzymatic extracts prepared by Flavourzyme, Ultraflo, and Kojizyme exhibited the greatest effects in DPPH free radical, alkyl radical scavenging activity and cell viability. Also, these enzymatic extracts had a higher antioxidant effect then commercial antioxidants in DPPH free radical and Alkyl radical scavenging activity. This study suggests that P. littoralis might be a useful source of natural antioxidants for the development of dietary supplements. 통계 이 연구에서 실험값은 SPSS package program의 paired t-test로 검정하여 통계 값을 구했으며, 모든 실험값은 평 균 ± 표준편차(Mean ± standard deviation)로 나타내었다.

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“…There are reports that marine macroalgae belonging to Phaeophyta group possess antitumor activity, and sterols from Sargassum carpophyllum exhibited cytotoxic activity against several cultured cell lines (Tang et al, 2002). Many researches have revealed that bioactive compounds including fucoidans, terpenes, stypoldione, sterols, polyunsaturated fatty acids and phenolic compounds have anticancer and cytotoxic activity (Gerwick et al, 1993;Carte, 1996;Synytsya et al, 2010). One way analysis shows significant (p<0.05) difference for the various concentration of Sargassum sp.…”

Section: Discussionmentioning

confidence: 99%

Screening for in vitro Cytotoxic Activity of Seaweed, Sargassum sp. Against Hep-2 and MCF-7 Cancer Cell Lines

Mary

Vinotha²,

Pradeep³

2012

Asian Pacific Journal of Cancer Prevention

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Discovery of anticancer drugs that kill or disable tumor cells in the presence of normal cells without undue toxicity is a potential challenge for therapeutic care. Several papers in the literature have emphasized the potential implications of marine products such as seaweeds which exhibit antitumor activity. Study attempts to screen the antitumor effect of Sargassum sp, against chosen cell lines such as MCF-7 (Breast cancer) and Hep-2 (Liver Cancer). Ethanol extract of Sargassum sp. was concentrated using a Soxhlet apparatus and dissolved in DMSO. In vitro cytotoxic activity of Sargassum sp at various concentrations (100 µg/ml-300 µg/ml) screened for antitumor effect against the chosen cell lines using MTT assay (3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide, a yellow tetrazole). The study documented that the percentage of cell viability has been reduced with increased concentration, as evidenced by cell death. Sargassum sp extract shows potential cytotoxic activity (P≤0.05) with IC 50 of 200 µg/ml and 250 µg/ml against Hep-2 and MCF-7 cell lines respectively. The ethanol fraction of Sargassum sp induced cell shrinkage, cell membrane blebbing and formation of apoptotic bodies with evidence of bioactive components as profound influencing factors for anti-tumor effects. Further research need to be explored for the successful application of Sargassum sp as a potent therapeutic tool against cancer.

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Structure and antitumour activity of fucoidan isolated from sporophyll of Korean brown seaweed Undaria pinnatifida

Cited by 393 publications

References 36 publications

Free radical scavenging activity of extracts from seaweeds Macrocystis pyrifera and Undaria pinnatifida: applications as functional food in the diet of prawn Artemesia longinaris

Free radical scavenging activity of extracts from seaweeds Macrocystis pyrifera and Undaria pinnatifida: applications as functional food in the diet of prawn Artemesia longinaris

Antioxidant Effect of Tropical Seaweed Pylaiella littoralis Extracts Collected from Chuuk Lagoon in Federated States of Micronesia

Screening for in vitro Cytotoxic Activity of Seaweed, Sargassum sp. Against Hep-2 and MCF-7 Cancer Cell Lines

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