Structure and antitumor activities of the water-soluble polysaccharides from Ganoderma tsugae mycelium

Peng, Yanfei; Zhang, Lina; Zeng, Fanbo; Kennedy, John F.

doi:10.1016/j.carbpol.2004.10.009

Cited by 127 publications

(63 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…lucidum (Bao et al, 2002;Zhao et al, 2010) and from the mycelia cultivated in liquid culture medium (Kim et al, 1993;Peng et al, 2005;. Some polysaccharides have also been isolated from the culture medium of growing mycelium (extracellular polysaccharides) (Sone et al, 1985).…”

Section: Ganoderma Polysaccharidesmentioning

confidence: 99%

“…In vivo Tumorigenicity assay: calculation of the tumor inhibition ratio (%) and enhancement of Sarcoma 180 solid tumor 12.9-55.06 % of inhibition ratio 11.5 -39.1 % enhancement of body weight ratio Peng et al, 2005 55 BALB/c mice -albino laboratory-bred strain of the house mouse from which a number of common sub-strains are derived; DEAEDiethylaminoethyl; GC -Gas chromatography; GLC -Gas liquid chromatography; HPGFC -High performance gel filtration chromatography; HP-GPC -High performance gel permeation chromatography; HPLC -High performance liquid chromatography; HPLC-FID -High performance liquid chromatography coupled to a flame ionization detector; ICR mice -Imprinting control regions, strain of albino mice distilled water and 0. FT-IR -Fourier transform infrared spectrophotometer; GC-Gas chromatography; GC-MS -Gas chromatography coupled to mass spectrometry; GLC-MS -Gas liquid chromatography coupled to mass spectrometry; GPC -Gel permeation chromatography; HPGPC -High performance gel permeation chromatography; HPLC -High performance liquid chromatography; HPSEC -High pressure size exclusion chromatography; IRInfrared spectroscopy; NMR -Nuclear magnetic resonance spectroscopy; PC -Paper chromatography; na -data not available.…”

Section: China (Fruiting Body) (Cultivated)mentioning

confidence: 99%

See 1 more Smart Citation

Chemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities

et al. 2015

View full text Add to dashboard Cite

This review aims to contribute to the growing knowledge on bioactive (antioxidant, antitumor and antimicrobial) properties of polysaccharides, glycoproteins and polysaccharidic extracts obtained from Ganoderma species. The chemical features were analyzed and related to correspondent bioactivities. ____________________________________________________________________ 2 Research highlightsChemical features of Ganoderma bioactive polysaccharides were discussed.Methods for extraction, isolation and identification were evaluated.Bioactivity of polysaccharidic extracts and purified compounds were discussed.Integration of data allowed deduction of structure-activity relationships.

show abstract

Section: Ganoderma Polysaccharidesmentioning

confidence: 99%

Section: China (Fruiting Body) (Cultivated)mentioning

confidence: 99%

Chemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Ganoderma tsugae is another commonly used species in Chinese herbal medicine and health food. It has attracted much attention because its polysaccharides have been demonstrated to have antitumor activities [7, 8]. In our previous studies, the G. tsugae extract increased IL-2 and decreased IL-4 cytokine production from splenocytes of BALB/c mice [9].…”

Section: Introductionmentioning

confidence: 99%

Effects of Triterpenoid-Rich Extracts of <i>Ganoderma tsugae</i> on Airway Hyperreactivity and Th2 Responses in vivo

Chen¹,

Lin²

2006

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Background: Airway inflammation and Th2 responses play central roles in allergic asthma. We have previously reported that Ganoderma tsugae supplementation could attenuate airway inflammation in the murine model. Since it remains unclear which part of the G. tsugae exerts this effect on allergic asthma in vivo, this study was meant to investigate if triterpenoid extracts have anti-inflammatory effects on airway responses and regulatory effects on Th2 responses. Methods: BALB/c mice sensitized intraperitoneally and challenged with ovalbumin (OVA) were treated with either triterpenoid-rich extracts (TRE) of G. tsugae or prednisolone for 2 weeks. The effects of TRE on bronchial airway hyperresponsiveness (AHR), airway inflammation, serum antigen-specific antibody levels, and cytokine secretions from splenocytes were evaluated. Results: TRE supplementation significantly decreased AHR and reduced the total infiltrating leukocytes and eosinophils, as well as the levels of inflammatory mediators, such as interleukin (IL)-4, IL-5 and eotaxin in bronchoalveolar lavage fluid when compared with those of the control group. Lung histology also showed less cell recruitment and lung damage. TRE supplements suppressed IL-5 secretions from OVA-stimulated splenocytes, but did not affect the cell number of splenocytes, which was also reduced by prednisolone. Although OVA-specific immunoglobulin E levels were not significantly different among the groups, a lower level of OVA-specific immunoglobulin G1, another Th2-related antibody, was found in TRE and prednisolone treatment. Conclusions: TRE of G. tsugae exert anti-inflammatory effects on airway responses and attenuate Th2 responses without the overall immunosuppression effects in allergic murine models of asthma.

show abstract

“…In addition, other polysaccharides derived from mushroom were also studied. In an investigation, the efficacy of Ganoderma tsugae which is a famous traditional medicine was proved; the polysaccharide fractions are possessing a significant antitumor activity against solid tumor Sarcoma 180 with inhibition ratio beyond 50 % (Peng et al 2005). In a study, the antitumor activity of polysaccharides extracted from Ganoderma lucidum on the human breast cancer cell in vitro has been evaluated by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay.…”

Section: Bioactivitiesmentioning

confidence: 99%

Polysaccharides from Medicinal Mushrooms and Their Antitumor Activities

Chen¹,

Li²

2015

Polysaccharides

View full text Add to dashboard Cite

Structure and antitumor activities of the water-soluble polysaccharides from Ganoderma tsugae mycelium

Cited by 127 publications

References 22 publications

Chemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities

Chemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities

Effects of Triterpenoid-Rich Extracts of <i>Ganoderma tsugae</i> on Airway Hyperreactivity and Th2 Responses in vivo

Polysaccharides from Medicinal Mushrooms and Their Antitumor Activities

Contact Info

Product

Resources

About