Structure and antiherpetic activity among the Tannins

Takechi, Masayuki; Tanaka, Yasuo; Takehara, Manabu; Nonaka, Gen‐ichiro; Nishioka, Itsuo

doi:10.1016/s0031-9422(00)83018-6

Cited by 155 publications

(83 citation statements)

References 25 publications

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“…However, tannins often have high cytotoxic activities (Takechi et al, 1985;Jiang et al, 2008), which may be non-specific. Although generally speaking condensed tannins are less toxic than hydrolysable tannins, instances of toxicity to livestock due to condensed tannins have been reported (Singleton, 1981;Oelrichs et al, 1994).…”

Section: Discussionmentioning

confidence: 99%

“…Plant extracts may simultaneously have high anthelmintic activities and high non-selective cytotoxic activities. Results from numerous studies suggest that tannin components in plant extracts have anthelmintic and cytotoxic activities (Takechi et al, 1985;Bizimenyera et al, 2006;Jiang et al 2008;Ramalingam et al, 2010). Tannins have been linked to a case of poisoning in avian species (Kinde, 1988).…”

Section: Introductionmentioning

confidence: 99%

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Anthelmintic and cytotoxic activities of extracts of Markhamia obtusifolia Sprague (Bignoniaceae)

Nchu¹,

Githiori²,

McGaw³

et al. 2011

Veterinary Parasitology

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The anthelmintic activity of Markhamia obtusifolia Sprague (Bignoniaceae) leaf extracts was evaluated against the ruminant gastrointestinal nematode parasite Trichostrongylus colubriformis (Nematoda: Strongylida) using the in vitro egg hatch test. Also, the cytotoxic activity of aqueous extracts of M. obtusifolia was evaluated in cell line cytotoxicity assays. The results indicated that the effective concentration (EC 50 ) for the water extract of M. obtusifolia leaves (0.46 mg/mL; Confidence Interval[CI] 0.3-0.5 mg/mL) was significantly lower than the EC 50 for the acetone extract of M. obtusifolia (0.8 mg/mL; CI 0.7-1 mg/mL). Aqueous extracts were twice as potent as the acetone extracts. The ED 90 (0.2 mg/mL; CI 0.1-0.02) for thiabendazole (positive control) was significantly lower than the EC 90 for the water extract of M. obtusifolia 2 (10.7 mg/mL; CI 8.3-13.7 mg/mL). In the cytotoxicity bioassay, the lethal concentration (LC 50 ) for the aqueous extract of M. obtusifolia was 0.476 mg/mL, which was relatively high (low toxicity) in comparison to the highly toxic berberine (LC 50 = 9.80 µg/mL). The current study showed that M. obtusifolia plant extracts possess anthelmintic activity and are relatively non-cytotoxic, thus providing support for their use in traditional veterinary practices.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anthelmintic and cytotoxic activities of extracts of Markhamia obtusifolia Sprague (Bignoniaceae)

Nchu¹,

Githiori²,

McGaw³

et al. 2011

Veterinary Parasitology

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“…It was reported that procyanidins inhibited platelet aggregation [40] and had also successfully inhibited the oxidation of low-density lipoprotein (LDL) as well as contributed to reduction in risks of heart disease associated with atherosclerosis [41]. In addition, procyanidins performed very well as anti-inlammatory [42,43], antimutagens [44], anticancer [45][46][47], and antiviral [48] agents.…”

Section: Biological Activitiesmentioning

confidence: 99%

Grape Seed Nutraceuticals for Disease Prevention: Current Status and Future Prospects

Ananga¹,

Obuya²,

Ochieng³

et al. 2017

Phenolic Compounds - Biological Activity

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Grapes (Vitis spp.) are consumed as fresh table fruits, raisins, and processed into wine, juice, jelly and other value-added products. Grapes contain bioactive secondary metabolites (polyphenols), such as proanthocyanins (oliogemeric lavonoids), lavonoids (catechin, epicatechin, and quercetin), and anthocyanins. They have non-lavonoids such as hydroxycinnamic acids (p-coumaric, cinnamic, cafeic, gentisic, ferulic, and vanillic acids), and hydroxybenzoic acids: trihydroxy stilbenes (resveratrol and polydatin). These phytochemicals are of economic importance to pharmaceutical, food and cosmetic industries. Nutraceuticals from grape seeds have potential cardioprotective, anti-cancer, antioxidant, anti-inlammatory, antiviral, neuroprotective, hepatoprotective and antimicrobial properties. Grape seed nutraceuticals have been re-invented in the past few years as a new paradigm in human medicine. In particular, nutraceuticals from grape seeds have been used in stopping wound bleeding, anti-inlammatory agents, pain relief, and anti-diarrhea. In addition, they can be used for the treatment of various human health conditions such as cancer, cholera, smallpox, and nausea as well as eye infections, skin, kidney, liver diseases, etc. Nowadays, consumers are demanding for healthy supplements and personal care products with natural ingredients. Therefore, the present review highlights recent developments and future opportunities of grape seed nutraceuticals for the prevention of human diseases.

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“…3 Also, many compounds containing 3,4-dihydrocoumarins rings possess important biological activities; for example, inhibitors of aldose reductase, 4 protein kinases 5 and antiherpetic. 6 In 2008, detailed structure-activity relationships on splitomicin derivatives and their inhibition of recombinant Sirt2 were presented by Jung. 7 3,4-Dihydroquinolin-2(1H)-one skeletons are rarely found in naturally occurring substances, but they possess varied and powerful biological properties; [8][9] for example, they have been proposed as a pharmacophore for norepinephrine transporter(NET) inhibition.…”

Section: Introductionmentioning

confidence: 99%

A synthesis of ferrocenyl dihydrocoumarin and ferrocenyl dihydroquinolin-2(1H)-ones

Wang¹,

Fan²,

Luo³

et al. 2011

Arkivoc

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A series of phenols have been used to react with ferrocenyl cinnamic acid, and the results of 1 H NMR and crystal structures have shown that only resorcinol and 2-naphthalenol can get ring closure products, while the others only get esterified products. This is because resorcinol and 2-naphthalenol have higher electronic density in ortho-site of hydroxyl than other phenols used in this work. Ten ferrocenyl dihydroquinolin-2(1H)-ones are synthesized by hydroarylation of ferrocenyl acrylic amides in the presence of TFA, and an interpretation is also given to the experimental fact that strong acid can not catalyze hydroarylation of acrylic anilides to dihydroquinolones.

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Structure and antiherpetic activity among the Tannins

Cited by 155 publications

References 25 publications

Anthelmintic and cytotoxic activities of extracts of Markhamia obtusifolia Sprague (Bignoniaceae)

Anthelmintic and cytotoxic activities of extracts of Markhamia obtusifolia Sprague (Bignoniaceae)

Grape Seed Nutraceuticals for Disease Prevention: Current Status and Future Prospects

A synthesis of ferrocenyl dihydrocoumarin and ferrocenyl dihydroquinolin-2(1H)-ones

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