Structure and anticoagulant activity of a sulfated fucan from the sea cucumber Acaudina leucoprocta

He, Wentao; Sun, He; Su, Laijin; Zhou, Da‐Yang; Zhang, Xing; Deng, Shanggui; Chen, Yin

doi:10.1016/j.ijbiomac.2020.07.080

Cited by 39 publications

(20 citation statements)

References 28 publications

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“…The results showed that heparin cofactor II had inherent anticoagulant activity and specific antithrombin activity. 91 The specific sulfation mode and position of the glycosidic bonds in fucoidan confer its anticoagulation activity. Further studies on the mechanisms have shown that fucoidan strongly inhibits the internal coagulation pathway by targeting the intrinsic coagulation factor Xase.…”

Section: The Antithrombotic Effect Of Fucoidanmentioning

confidence: 99%

Application of fucoidan as treatment for cardiovascular and cerebrovascular diseases

Wang

Xu²,

Wei

et al. 2022

Therapeutic Advances in Chronic Disease

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Fucoidan is a marine polysaccharide. In recent years, fucoidan has attracted wide-scale attention from the pharmaceutical industries due to its diverse biological activities such as lipid-lowering, anti-atherosclerosis, and anticoagulation. This review clarifies the pharmacological effects of fucoidan in the treatment of human cardiovascular and cerebrovascular diseases. Fucoidan exerts a hypolipidemic effect by increasing the reverse transport of cholesterol, inhibiting lipid synthesis, reducing lipid accumulation, and increasing lipid metabolism. Inflammation, anti-oxidation, and so on have a regulatory effect in the process of atherosclerosis endothelial cells, macrophages, smooth muscle cells, and so on; fucoidan can not only prevent thrombosis through anticoagulation and regulate platelet activation, but also promote the dissolution of formed thrombi. Fucoidan has a neuroprotective effect, and also has a positive effect on the prognosis of the cardiovascular and cerebrovascular. The prospects of applying fucoidan in cardio-cerebrovascular diseases are reviewed to provide some theoretical bases and inspirations for its full-scale development and utilization.

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Section: The Antithrombotic Effect Of Fucoidanmentioning

confidence: 99%

Application of fucoidan as treatment for cardiovascular and cerebrovascular diseases

Wang

Xu²,

Wei

et al. 2022

Therapeutic Advances in Chronic Disease

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show abstract

“…These results indicated that there were strong interactions between the polysaccharide chains, through their many hydroxyl and sulfate groups. Peng et al (2019) reported that the sulfate group can cause twisting and interconversion between the sugar ring conformations, and He et al (2020) reported that hydroxyl groups are available to interact with other polysaccharide chains. These results demonstrated that the surface topographies of PHP1 was related to its molecular structure.…”

Section: Afm Analysismentioning

confidence: 99%

Structural characterization and in vitro fermentation by rat intestinal microbiota of a polysaccharide from Porphyra haitanensis

Chen

Tong

Zeng

et al. 2021

Food Research International

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“…The simplest structures are polymers of 3-or 4-linked monosulfated α-L-fucose residues, examples being highly regular polysaccharides [-3)-α-L-Fuc2S-(1-] n from Stichopus horrens [21,22] and Stichopus herrmanni [23]. Similar 3-linked FS, with a non-regular distribution of sulfate groups, was isolated from Acaudina leicoprocta [24], whereas 4-linked FSs, namely, [-4)-α-L-Fuc3S-(1-] n and [-4)-α-L-Fuc2S-(1-] n , were found in Holothuria fuscopunctata and Thelenota ananas, respectively [22]. Structures of linear FSs are often represented as regular molecules built up of differently sulfated tetrasaccharide repeating units.…”

Section: Introductionmentioning

confidence: 99%

Fucose-Rich Sulfated Polysaccharides from Two Vietnamese Sea Cucumbers Bohadschia argus and Holothuria (Theelothuria) spinifera: Structures and Anticoagulant Activity

et al. 2022

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Fucosylated chondroitin sulfates (FCSs) FCS-BA and FCS-HS, as well as fucan sulfates (FSs) FS-BA-AT and FS-HS-AT were isolated from the sea cucumbers Bohadschia argus and Holothuria (Theelothuria) spinifera, respectively. Purification of the polysaccharides was carried out by anion-exchange chromatography on DEAE-Sephacel column. Structural characterization of polysaccharides was performed in terms of monosaccharide and sulfate content, as well as using a series of non-destructive NMR spectroscopic methods. Both FCSs were shown to contain a chondroitin core [→3)-β-d-GalNAc-(1→4)-β-d-GlcA-(1→]n bearing sulfated fucosyl branches at O-3 of every GlcA residue in the chain. These fucosyl residues were different in pattern of sulfation: FCS-BA contained Fuc2S4S, Fuc3S4S and Fuc4S at a ratio of 1:8:2, while FCS-HS contained these residues at a ratio of 2:2:1. Polysaccharides differed also in content of GalNAc4S6S and GalNAc4S units, the ratios being 14:1 for FCS-BA and 4:1 for FCS-HS. Both FCSs demonstrated significant anticoagulant activity in clotting time assay and potentiated inhibition of thrombin, but not of factor Xa. FS-BA-AT was shown to be a regular linear polymer of 4-linked α-L-fucopyranose 3-sulfate, the structure being confirmed by NMR spectra of desulfated polysaccharide. In spite of considerable sulfate content, FS-BA-AT was practically devoid of anticoagulant activity. FS-HS-AT cannot be purified completely from contamination of some FCS. Its structure was tentatively represented as a mixture of chains identical with FS-BA-AT and other chains built up of randomly sulfated alternating 4- and 3-linked α-L-fucopyranose residues.

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Structure and anticoagulant activity of a sulfated fucan from the sea cucumber Acaudina leucoprocta

Cited by 39 publications

References 28 publications

Application of fucoidan as treatment for cardiovascular and cerebrovascular diseases

Application of fucoidan as treatment for cardiovascular and cerebrovascular diseases

Structural characterization and in vitro fermentation by rat intestinal microbiota of a polysaccharide from Porphyra haitanensis

Fucose-Rich Sulfated Polysaccharides from Two Vietnamese Sea Cucumbers Bohadschia argus and Holothuria (Theelothuria) spinifera: Structures and Anticoagulant Activity

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