Structure and anticoagulant activity of a sulfated galactan from the red alga, Gelidium crinale. Is there a specific structural requirement for the anticoagulant action?

Edematogenic activity of a sulfated galactan from the red marine algaeGelidium crinale

“…This association had already been described for the anticoagulant activity of other sulfated galactans (Farias et al, 2000), but also for that obtained from G. crinale (Pereira et al, 2005). Thus, the present study suggests that SG-Gc may be used as an important tool in the investigation of initial-phase inflammatory processes.…”

“…It contains an isolated sulfated galactan that presents a linear polysaccharide of alternating α-1→3 and 1→4-galactopyranose units with a variable sulfation pattern in which the 2,3-disulfated residues occur as ~15% of total galactan ( Figure 1A). Similar to λ carrageenan, there is no evidence of 3,6-anhydro in α-galactopyranose (Pereira et al, 2005). The galactan of G. crinale was shown to present anticoagulant effect, as it inhibits thrombin and factor Xa by antithrombin and heparin cofactor II.…”

“…The galactan of G. crinale was shown to present anticoagulant effect, as it inhibits thrombin and factor Xa by antithrombin and heparin cofactor II. It also presents antithrombotic effect via inhibition of venous and arterial thrombosis in rats (Pereira et al, 2005;Fonseca et al, 2008). However, its inflammatory role was not described yet.…”

“…crinale was collected at Pacheco beach, Caucaia-CE, Brazil, and the voucher specimen (nº 35.579) deposited in the Prisco Bezerra Herbarium-Federal University of Ceará. SG-Gc was extracted and purified by ion exchange chromatography in diethylaminoethyl-cellulose (DEAEcellulose) column (Pereira et al, 2005).…”

Isolamento, fracionamento e atividade anticoagulante de iota-carragenanas da Solieria filiformis

“…PS de algas marinhas vermelhas ocorrem na forma de galactanas sulfatadas (PEREIRA et al, 2005;SILVA et al, 2010), de fucanas sulfatadas nas algas pardas (MOURÃO, 2004;AZEVEDO et al, 2009) e, nas algas verdes, os mais encontrados são as arabino-galactanas e as raminoses (GHOSH et al, 2004;ZHANG et al, 2008).…”