Structure and Antibacterial Activity of Bi-cyclohexanone Pentaerythritol Ketal

Abstract

Abstract. Cyclohexanone pentaerythritol ketal was synthesized from cyclohexanone and pentaerythritol by condensation using NaHSO 4 as catalyst and characterized by NMR and MS spectrum. Furthermore, the structure of the tile compound was confirmed by single-crystal X-ray diffraction. It crystallizes in orthorhombic space group, P 21, with a unit cell dimensions of a = 11.1214(9) Å, b = 13.9216(6) Å and c = 11.6658(10) Å. In the crystal, there are two independent molecules with different conformation, varying both in bond lengths and angles. In each molecular, there are four six-membered cycles, two cyclohexyl groups and two 1,3-dioxane groups. The four six-membered cycles all display a typical stable boat conformation. The stacking interaction is responsible for the crystal's 1-D supra-molecular structure. The thermal gravimetric analysis (TGA) indicates the title compound is stable below 200°C, and the remaining weight ratio is less than 9% above 300°C. This compound was evaluated for their in vitro antimicrobial activity against six bacteria (S. aureus, S. epidermidis, M. luteus, E. coli, K. pneumoniae, A. fumigatus). It some anti-inflammatory activity against the tested bacteria and the inhibition is depending on the concentration.