Structure and Antibacterial Activity of Cinnamic Acid Related Compounds.

Natural Cinnamic Acids, Synthetic Derivatives and Hybrids with Antimicrobial Activity

“…The acid 3,4-methylenedioxycinnamic acid ( 10 ) has been reported to inhibit Mycobacterium tuberculosis H 37 Rv with one report displaying an MIC value of 312 µM [60] and the other an MIC value higher than 520 µM [85]. The effect of the position of the nitro group on antimicrobial activity suggest that 4-nitrocinnamic acid ( 11 ) is more active than 3-nitrocinnamic acid ( 12 ), however the comparison data results from two different studies [44,86]. The seminal report from 1940, found that none of the positional isomers of nitrocinnamic acid inhibited S. aureus or E. coli at the highest dilution tested [87].…”

“…Although the nitro groups can be readily reduced to amino groups, only 4-aminocinnamic ( 13 ) acid has been evaluated for its antimicrobial properties. This acid showed inhibitory activity of B. subtilis and E. coli with respective MIC values of 602 and 708 µM [86]. No information on the antimicrobial properties of the positional isomers of 4-aminocinnamic acid could be found.…”

Synergistic interaction of phenylpropanoids with antibiotics against bacteria

“…The benzene or phenol ring structure in the phenylpropanoids helps them to cross cellular membranes and exert their biological activities. The antibacterial activity of cinnamic acid derivatives has been well studied with main emphasis on the phenyl ring or carboxyl group present in them (Tonari et al, 2002). Owing to the importance of the cinnamic acids as antibacterial agents, the present study was designed to understand the interaction of a few of these with different classes of antibiotics against Gram-positive and -negative bacteria using chequerboard and time-kill curve assays.…”

Microwave‐enhanced, solvent‐free synthesis of singly and doubly 13C‐labelled trans‐cinnamic acid at the α‐ and β‐carbon positions

“…Recently, they have been applied as antibacterial agents for suppression of bacterial growth [1][2][3] or as a monomer unit to modify the properties of polymer materials. 4,5 Trans-cinnamic acid undergoes a [2+2] cycloaddition reaction under photoirradiation, and therefore it has a potential application in memory storage materials.…”