Structure and activity of nanozymes: Inspirations for de novo design of nanozymes

Wang, Zhuoran; Zhang, Ruofei; Yan, Xiyun; Fan, Kelong

doi:10.1016/j.mattod.2020.08.020

Cited by 506 publications

(322 citation statements)

References 213 publications

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“…[ 29 ] In another work designed by An et al ., the selectivity of Fe 3 O 4 nanozyme‐based tumor catalytic therapy was augmented via the addition of ascorbic acid, an essential micronutrient to selectively trigger oxidative stress in cancer cells under pharmacological dosage without harming normal cells. [ 7c ]…”

Section: Fe3o4 Nanozymes For Tumor Catalytic Therapymentioning

confidence: 99%

“…Nevertheless, the selectivity of Fe 3 O 4 nanozymes has plenty of room for improvement. [ 7c ] On this basis, strategies such as augmenting Fe 3 O 4 nanozymes’ catalytic activity by in situ near‐infrared laser irradiation or encapsulating Fe 3 O 4 nanozymes into carriers with tumor microenvironment triggered release capability have been designed. [ 95 ] Moreover, by means of specific surface modification, it could be feasible to inhibit the POD‐like activity of Fe 3 O 4 nanozymes during the delivery process, and then activate it at the tumor site in a stimuli‐responsive manner.…”

Section: Conclusion and Perspectivementioning

confidence: 99%

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Nanozyme for tumor therapy: Surface modification matters

et al. 2021

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As the next generation of artificial enzymes, nanozymes have shown unique properties compared to its natural counterparts, such as stability in harsh environment, low cost, and ease of production and modification, paving the way for its biomedical applications. Among them, tumor catalytic therapy mediated by the generation of reactive oxygen species (ROS) has made great progress mainly from the peroxidase-like activity of nanozymes. Fe 3 O 4 nanozymes, the earliest type of nanomaterial discovered to possess peroxidase-like activity, has consequently received wide attention for tumor therapy due to its ROS generation ability and tumor cell killing ability. However, inconsistent results of cytotoxicity were observed between different reports, and some even showed the scavenging of ROS in some cases. By collectively studying these inconsistent outcomes, we raise the question whether surface modification of Fe 3 O 4 nanozymes, either through affecting peroxidase activity or by affecting the biodistribution and intracellular fate, play an important role in its therapeutic effects. This review will go over the fundamental catalytic mechanisms of Fe 3 O 4 nanozymes and recent advances in tumor catalytic therapy, and discuss the importance of surface modification. Employing Fe 3 O 4 nanozymes as an example, we hope to provide an outlook on the improvement of nanozyme-based antitumor activity. K E Y WO R D S cytotoxicity, Fe 3 O 4 nanozymes, peroxidase-like activity, surface modification, tumor catalytic therapy This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Section: Fe3o4 Nanozymes For Tumor Catalytic Therapymentioning

confidence: 99%

Section: Conclusion and Perspectivementioning

confidence: 99%

Nanozyme for tumor therapy: Surface modification matters

et al. 2021

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“…Some of the reviews involved the research progress of nanozymes in a particular field [5,21,27,43,44]. Some researchers organized and revealed the natural activities and working mechanisms of specific nanozymes [45][46][47][48][49]. In 2019, Huang et al [50] systematically discussed the classification, intrinsic nature, enzymatic mechanisms and potential applications of nanozymes for the first time.…”

Section: Introductionmentioning

confidence: 99%

A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

et al. 2021

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Since the ferromagnetic (Fe3O4) nanoparticles were firstly reported to exert enzyme-like activity in 2007, extensive research progress in nanozymes has been made with deep investigation of diverse nanozymes and rapid development of related nanotechnologies. As promising alternatives for natural enzymes, nanozymes have broadened the way toward clinical medicine, food safety, environmental monitoring, and chemical production. The past decade has witnessed the rapid development of metal- and metal oxide-based nanozymes owing to their remarkable physicochemical properties in parallel with low cost, high stability, and easy storage. It is widely known that the deep study of catalytic activities and mechanism sheds significant influence on the applications of nanozymes. This review digs into the characteristics and intrinsic properties of metal- and metal oxide-based nanozymes, especially emphasizing their catalytic mechanism and recent applications in biological analysis, relieving inflammation, antibacterial, and cancer therapy. We also conclude the present challenges and provide insights into the future research of nanozymes constituted of metal and metal oxide nanomaterials.

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“…However, the most important advantage of nanozymes is their size/composition-dependent activity. It appears that the enzymatic activities of nanozymes are closely related to their size, surface lattice, surface modification, and composition [ 5 ]. This allows the design of materials with a broad range of catalytic activity simply by varying shape, structure, and composition.…”

Section: Introductionmentioning

confidence: 99%

Prussian Blue: A Nanozyme with Versatile Catalytic Properties

Estelrich

Busquets

2021

IJMS

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Nanozymes, nanomaterials with enzyme-like activities, are becoming powerful competitors and potential substitutes for natural enzymes because of their excellent performance. Nanozymes offer better structural stability over their respective natural enzymes. In consequence, nanozymes exhibit promising applications in different fields such as the biomedical sector (in vivo diagnostics/and therapeutics) and the environmental sector (detection and remediation of inorganic and organic pollutants). Prussian blue nanoparticles and their analogues are metal–organic frameworks (MOF) composed of alternating ferric and ferrous irons coordinated with cyanides. Such nanoparticles benefit from excellent biocompatibility and biosafety. Besides other important properties, such as a highly porous structure, Prussian blue nanoparticles show catalytic activities due to the iron atom that acts as metal sites for the catalysis. The different states of oxidation are responsible for the multicatalytic activities of such nanoparticles, namely peroxidase-like, catalase-like, and superoxide dismutase-like activities. Depending on the catalytic performance, these nanoparticles can generate or scavenge reactive oxygen species (ROS).

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Structure and activity of nanozymes: Inspirations for de novo design of nanozymes

Cited by 506 publications

References 213 publications

Nanozyme for tumor therapy: Surface modification matters

Nanozyme for tumor therapy: Surface modification matters

A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

Prussian Blue: A Nanozyme with Versatile Catalytic Properties

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