Structure–activity relationships studies of quinoxalinone derivatives as aldose reductase inhibitors

Electrochemical Dehydrogenative Cross‐Coupling of Quinoxalin‐2(1H)‐ones with Amines for the Synthesis of 3‐Aminoquinoxalinones

“…[1] In particular, the 3-aminoquinoxalinone motif is found widely in bioactive compounds, such as antibacterial, antiviral, anticancer, anti-diabetic, and anti-inflammatory agents. [2] Consequently, many synthetic strategies have been developed for the synthesis of 3-aminoquinoxalinones, the most conventional approaches involving either the construction of the quinoxalin-2(1H)-one heterocycle or the nucleophilic substitution of quinoxalin-2(1H)-one derivatives bearing a halo or other leaving group. [3] The oxidative functionalization of CÀH bonds has emerged as an appealing method in organic chemistry, since the prefunctionalization of CÀH bonds is avoided.…”

Synthesis of Phenanthridine and Quinoxaline Derivatives viaCopper‐Catalyzed Radical Cyanoalkylation of Cyclobutanone Oxime Esters and Vinyl Azides

“…Recently, vinyl azides have become a class of versatile synthon for organic synthesis. [ 6 ] And cyclization of vinyl azides utilizing radical addition reaction provides a new method to prepare phenanthridine and quinoxaline derivatives (Scheme 1a). [ 7 ]…”

Electrosynthesis of C3 Alkoxylated Quinoxalin‐2(1H)‐ones through Dehydrogenative C–H/O–H Cross‐Coupling

“…Meanwhile, quinoxalin‐2(1 H )‐ones have attracted much attention due to their abundant existence in anti‐inflammatory, antineoplastic, antithrombotic agents and aldose reductase inhibitors Conventional installation of C–O bond at C3 of quinoxalin‐2(1 H )‐ones largely rely on the nucleophilic substitution between 3‐chloroquinoxalin‐2(1 H )‐ones and phenols (see Scheme a) . Tremendous efforts have been made to develop C–H/O–H direct coupling to avoid the use of pre‐functionalized substrates and strong basic conditions during the synthesis of 3‐alkoxylated quinoxalin‐2(1 H )‐ones.…”