Structure-activity relationships reveal a 2-furoyloxychalcone as a potent cytotoxic and apoptosis inducer for human U-937 and HL-60 leukaemia cells

Rosario, Henoc del; Saavedra, Ester; Brouard, Ignacio; González-Santana, Daniel; García, Celina; Spínola-Lasso, Elena; Tabraue, Carlos; Quintana, José; Estévez, Francisco

doi:10.1016/j.bioorg.2022.105926

Cited by 4 publications

(2 citation statements)

References 40 publications

(72 reference statements)

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“…The U-937 cells express the Fas antigen and are sensitive to TNF and anti-Fas antibodies. Therefore, they are widely used in cell cycle and apoptosis studies [ 155 , 156 , 157 ]. They are also used to evaluate new anticancer drugs and as an in vitro test system to identify contact sensitizers.…”

Section: Aml Cell Lines and Typesmentioning

confidence: 99%

Choosing the Right Cell Line for Acute Myeloid Leukemia (AML) Research

Skopek

Palusińska

Kaczor-Keller

et al. 2023

IJMS

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Immortalized cell lines are widely used in vitro tools in oncology and hematology research. While these cell lines represent artificial systems and may accumulate genetic aberrations with each passage, they are still considered valuable models for pilot, preliminary, and screening studies. Despite their limitations, cell lines are cost-effective and provide repeatable and comparable results. Choosing the appropriate cell line for acute myeloid leukemia (AML) research is crucial for obtaining reliable and relevant results. Several factors should be considered when selecting a cell line for AML research, such as specific markers and genetic abnormalities associated with different subtypes of AML. It is also essential to evaluate the karyotype and mutational profile of the cell line, as these can influence the behavior and response to the treatment of the cells. In this review, we evaluate immortalized AML cell lines and discuss the issues surrounding them concerning the revised World Health Organization and the French–American–British classifications.

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Section: Aml Cell Lines and Typesmentioning

confidence: 99%

Choosing the Right Cell Line for Acute Myeloid Leukemia (AML) Research

Skopek

Palusińska

Kaczor-Keller

et al. 2023

IJMS

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“…Del Rosário and collaborators (2022) [ 60 ], carried out the synthesis of 50 chalcones through a standard aldol condensation reaction of three acetophenones with three benzaldehydes. These compounds were evaluated by means of the inhibition capacity of the strains HL-60 and U-937.…”

Section: Chalcones With Anticancer Activitymentioning

confidence: 99%

Anticancer Activity of Chalcones and Its Derivatives: Review and In Silico Studies

et al. 2023

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Chalcones are direct precursors in the biosynthesis of flavonoids. They have an α,β-unsaturated carbonyl system which gives them broad biological properties. Among the biological properties exerted by chalcones, their ability to suppress tumors stands out, in addition to their low toxicity. In this perspective, the present work explores the role of natural and synthetic chalcones and their anticancer activity in vitro reported in the last four years from 2019 to 2023. Moreover, we carried out a partial least square (PLS) analysis of the biologic data reported for colon adenocarcinoma lineage HCT-116. Information was obtained from the Web of Science database. Our in silico analysis identified that the presence of polar radicals such as hydroxyl and methoxyl contributed to the anticancer activity of chalcones derivatives. We hope that the data presented in this work will help researchers to develop effective drugs to inhibit colon adenocarcinoma in future works.

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