Structure–activity relationships of trans-cinnamic acid derivatives on α-glucosidase inhibition

Sookkongwaree, Kasem; Roengsumran, Sophon; Petsom, Amorn; Ngamrojnavanich, Nattaya; Chavasiri, Warinthorn; Deesamer, Sujitra; Yibchok-anun, Sirintorn

doi:10.1016/j.bmcl.2004.03.037

Cited by 113 publications

(75 citation statements)

References 19 publications

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“…The absorbance was read at 580 nm with Acarbose as the positive control. a-glucosidase enzyme inhibition assay was done as described by Adisakwattana et al (2004) with acarbose as the positive control. The reaction was monitored by increase an in absorbance at 405 nm and compared with the enzyme reaction without the extract.…”

Section: Determination Of Antidiabetic Activitymentioning

confidence: 99%

Nutraceutical properties of cumin residue generated from Ayurvedic industries using cell line models

et al. 2016

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Spent cumin (SC), generated from Ayurvedic industry, was evaluated for its nutraceutical potential in terms of antioxidant, antidiabetic and anticancer properties, and compared with that of the raw cumin (RC). SC and RC seeds were extracted with ethyl acetate (E) and methanol (M). SCM (methanol extract) were rich in p-coumaric acid, ferulic acid, ellagic acid and cinnamic acid (6.4445, 5.8286, 2.1519, 4.3085 mg/g dry extract). SCM reduced Fe 2? ion (89.68 lM AA/g dry weight), scavenged DPPH radical (IC 50 -238.6 lg/mL), better a-amylase inhibition (IC 50 -337.22 lg/mL) and glucose uptake activity in 30.7% of L6 cells. SCM inhibited viability, retarded migration area up to 41.02%, arrested cell cycle at S phase and induced apoptosis in 2.45% of HT29 colon cancer cells. The results indicated that dietary interventions using nutraceutical food formulation made out of SC can play a significant role in the prevention and management of degenerative diseases.

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Section: Determination Of Antidiabetic Activitymentioning

confidence: 99%

Nutraceutical properties of cumin residue generated from Ayurvedic industries using cell line models

et al. 2016

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“…Adisakwattana et al [12] reported antidiabetic activity of the compounds and derivatives of cinnamic acid. They also studied the relationship between the substitution on the benzene ring of cinnamic acid and the activity of the α-glucosidase enzyme inhibition.…”

Section: Indones J Chem 2017 17 (1) 151 -160mentioning

confidence: 99%

“…Machilus philippinense Merr. flavonol glycosides contain cinnamic compounds that have been evaluated and have activities of α-glucosidase inhibitors of type IV from Bacillus stearothermophilus with IC 50 = 6.10 µm for compounds (12) and IC 50 = 1.00 µm for compound (13) [21].…”

Section: Natural Productsmentioning

confidence: 99%

Cinnamic Acid Derivatives as α-Glucosidase Inhibitor Agents

et al. 2017

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“…An example of such compounds is hydroxycinnamic acids (p-coumaric, caffeic, ferulic, and sinapic) and their derivatives (esters, amides, and glycosides) which possess a pool of biological activities, including and antidiabetic effects [28][29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Structure-Activity Relationships ofN-Cinnamoyl and Hydroxycinnamoyl Amides onα-Glucosidase Inhibition

Chochkova

Petrova

Stoykova

et al. 2017

Journal of Chemistry

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Currently, there is an increasing interest towards -glucosidase inhibition of various diseases including diabetes mellitus type 2, cancer, HIV, and B-and C-type viral hepatitis. Cinnamic acid derivatives have been shown to be potentially valuable as a new group of -glucosidase inhibitors. Therefore, herein, the -glucosidase inhibitory activity of trans-N-cinnamoyl and hydroxycinnamoyl amides was studied in vitro. Results revealed that the tested hydroxycinnamoyl amides (1-16) inhibited a-glucosidase with IC 50 s ranging between 0.76 and 355.1 g/ml. Compounds 1, 2, 5, 6, 9, 14, and 15 showed significant inhibition of yeast -glucosidase, being even more potent ones than the used positive inhibitor acarbose (IC 50 = 2.50 ± 0.21 g/ml).

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Structure–activity relationships of trans-cinnamic acid derivatives on α-glucosidase inhibition

Cited by 113 publications

References 19 publications

Nutraceutical properties of cumin residue generated from Ayurvedic industries using cell line models

Nutraceutical properties of cumin residue generated from Ayurvedic industries using cell line models

Cinnamic Acid Derivatives as α-Glucosidase Inhibitor Agents

Structure-Activity Relationships ofN-Cinnamoyl and Hydroxycinnamoyl Amides onα-Glucosidase Inhibition

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