Structure-Activity Relationships of Tetracyclines I: Inhibition of Cell Division and Protein and Nucleic Acid Syntheses in Escherichia coli W

Microbial Kinetics and Dependencies of Individual and Combined Antibiotic Inhibitors of Protein Biosynthesis

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The generation rate constants for the steady-state growth of antibiotic-inhibited Escherichia Although chloramphenicol and tetracycline may bind differently on the ribosomal complex (7,22,24,25,30), they have been shown (12,27) to be "kinetically equivalent" in their growthinhibitory action against Escherichia coli. Erythromycin and the lincosaminide antibiotics are also presumed to be different in the mechanistic details of their action at the ribosomal site (3, 31), yet they demonstrate "kinetic equivalence" except where allosteric effects at the binding sites may yield antagonistic reactions (13,20,21,27).

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“…Erythromycin and the lincosaminide antibiotics are also presumed to be different in the mechanistic details of their action at the ribosomal site (3, 31), yet they demonstrate "kinetic equivalence" except where allosteric effects at the binding sites may yield antagonistic reactions (13,20,21,27). This paper presents the results of studies to determine the effects of combinations chosen from tetracycline, chloramphenicol, erythromycin, and the lincosaminides on the generation rate of E. coli and rationalizes the microbial kinetic dependencies on the concentrations of the separate and combined antibiotics.…”

MIP-based extraction techniques for the determination of antibiotic residues in edible meat samples: Design, performance & recent developments

“…(M. L. Nelson & Levy, 2011) Studies show that protein synthesis inhibition via binding to the ribosomal 30S subunit is TCs primary mode of action. (Chopra & Roberts, 2001;Miller et al, 1971) chelating activity, and they can bind to metallic cations of elements such as iron, calcium, aluminum, and magnesium. (Grenier et al, 2000;Neuvonen, 1976) J o u r n a l P r e -p r o o f…”

Comparison of Tetracycline Action on Staphylococcus aureus and Escherichia coli by Microbial Kinetics

“…Studies on the action of tetracycline against E. coli by the kinetics of microbial growth (2,(10)(11)(12)(13)(14)24) permitted not only the characterization of drug-receptor interactions in the biophase but also an elucidation of the possible mode of tetracycline action on the cells. Recently, comparative studies on the action of some drugs on S. aureus and E. coli by microbial growth kinetics (16) have revealed relative differences in the kinetics and dependencies related to modes of drug action on gram-positive and gram-negative organisms.…”