Structure-Activity Relationships of Sesquiterpene Lactones

In Silico Prediction and Experimental Evaluation of Furanoheliangolide Sesquiterpene Lactones as Potent Agents against Trypanosoma brucei rhodesiense

“…The structure-activity relationships of their various pharmacological and toxicological effects have been reviewed extensively (24,25). Most of these activities have been attributed to the potential of many STLs to form covalent bonds with biological nucleophiles, especially cysteine residues of proteins.…”

Inhibition of Myb-dependent gene expression by the sesquiterpene lactone mexicanin-I

“…[20][21][22] STLs are the active constituents of a variety of medicinal plants used in traditional medicine for the treatment of inflammatory diseases. 20 In recent years, the anti-cancer properties of various STLs have attracted interest, and extensive research has been carried out to characterize the anti-cancer activity and the potential chemotherapeutic application of STLs.…”

“…Suppression of c-Myb-induced gene activation might therefore be a valuable therapeutic strategy. 2 Here, we have investigated the potential of sesquiterpene lactones (STLs), a class of natural products that possess a variety of biological activities and have been identified as active constituents of various medicinal plants, [20][21][22] to inhibit the activation of Myb-inducible genes. We have generated a fluorescence-based cell system that allows screening of STLs and other compounds for their ability to suppress the activation of a Myb-inducible reporter gene.…”

Psilostachyin C: a natural compound with trypanocidal activity

“…STLs are C-15 terpenoid compounds and represent an important and biogenetically homogeneous group of secondary metabolites present in higher plants [11]. They display great diversity and an enormously broad spectrum of biological activities, including antiprotozoal activity [12][13][14][15].…”