Abstract:Structure-activity relationships of N-aryl-4-substituted phthalimides were analyzed using the adaptive least-squares method. Significant factors inferred were : the sum of the hydrophobicity of substituents on both phenyl rings, the sum of the steric constants of the substituents at both ortho-positions of the N-aryl ring and the presence of acidic substituents, including substituents readily being converted into the acid at the 4-position of the phthalimide moiety.
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