Structure-activity relationships of N-aryl-4-substituted phthalimides in the control of Plasmodiophora disease.

Abstract

Structure-activity relationships of N-aryl-4-substituted phthalimides were analyzed using the adaptive least-squares method. Significant factors inferred were : the sum of the hydrophobicity of substituents on both phenyl rings, the sum of the steric constants of the substituents at both ortho-positions of the N-aryl ring and the presence of acidic substituents, including substituents readily being converted into the acid at the 4-position of the phthalimide moiety.