Structure-activity relationships in papain and bromelain ligand interactions

Hansch, Corwin; Smith, R. Nelson; Rockoff, Arleen; Calef, Daniel F.; Jow, P. Y. C.; Fukunaga, James Y.

doi:10.1016/0003-9861(77)90372-1

Cited by 37 publications

(11 citation statements)

References 15 publications

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“…Bromelain is an enzyme derived from pineapple that degrades large proteins and solublizes mucins (17, 33). Specifically, it cleaves proteins similar to papain, a nonspecific endopeptidase (15, 17, 24, 33, 42, 43). Unlike papain, however, which can be inhibited by cystatins in saliva (39), bromelain is not affected by cystatins (36).…”

Section: Discussionmentioning

confidence: 99%

Inhibitory effects of whole and parotid saliva on immunomodulators

Wozniak

Arribas

Leigh

et al. 2002

Oral Microbiology and Immunology

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Based on the presence of cytokines in whole saliva and their association with resistance and susceptibility to infectious disease, the present study was designed to evaluate the diagnostic potential of a large panel of cytokines and chemokines in saliva. Despite the endogenous presence of Th1/Th2 and pro-inflammatory cytokines and several chemokines in whole and parotid saliva of most individuals tested, the detection of known concentrations of several recombinant cytokines and chemokines was inhibited immediately following their addition to each type of saliva. In contrast, purified immunoglobulins were unaffected by either whole or parotid saliva. Further studies revealed that the inhibition of immunoreactivity involved sequestration of the majority of cytokines affected and degradation of chemokines. These results suggest that absolute concentrations of cytokines/chemokines may not be fully detectable in saliva. Therefore, the diagnostic value of any cytokine/chemokine is questionable and should be evaluated independently as such.

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Section: Discussionmentioning

confidence: 99%

Inhibitory effects of whole and parotid saliva on immunomodulators

Wozniak

Arribas

Leigh

et al. 2002

Oral Microbiology and Immunology

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show abstract

“…He and his workers (Hansch et al, 1977) demonstrated the following relationship for a set of esters binding to the enzyme papain.…”

mentioning

confidence: 99%

Guidance Document on the Validation of (Quantitative) Structure-Activity Relationship [(Q)SAR] Models

2014

OECD Series on Testing and Assessment

158

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“…The work of Hansch et al [20] provides an example of the use of QSAR to give information concerning mechanism. They demonstrated the following relationship for a set of esters binding to the enzyme papain.…”

Section: Why Look For Quantitative Relationships?mentioning

confidence: 99%

Molecular Design

Livingstone

2009

A Practical Guide to Scientific Data Analysis

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Structure-activity relationships in papain and bromelain ligand interactions

Cited by 37 publications

References 15 publications

Inhibitory effects of whole and parotid saliva on immunomodulators

Inhibitory effects of whole and parotid saliva on immunomodulators

Guidance Document on the Validation of (Quantitative) Structure-Activity Relationship [(Q)SAR] Models

Molecular Design

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