Structure-Activity Relationships in Certain Anthelmintics

Craig, J. C.; Tate, M. E.

doi:10.1007/978-3-0348-7041-2_2

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2006

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“…A variety of natural products such as alkaloids also contain the pyrimidine ring system, these include hypoxanthine and xanthine, which occur in tea, and caffeine and theophylline (the constituents of tea leaves). Phenothiazine derivatives possess diverse biological activities like antiparkinsonian [10][11] , anticonvulsant 12 , antihistaminic 13 , antihelmatic 14 , antiviral 15 , antiparasitic 16 and CNS depressant 17 .…”

Section: Introductionmentioning

confidence: 99%

Synthesis of 2‐[4‐(10H‐Substituted Phenothiazine‐3‐yl)‐6‐Pyrimidin‐2‐Phenylthiol/ol/amine/thiol] Pyrroles

Narule

Meshram

Santhakumari

et al. 2006

Journal of Chemistry

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2-[4-Hydroxy benz-1(propene-1-one)]Pyrrole II on treatment with phenyl thiourea, guanidine carbonate, urea and thiourea in alcoholic KOH yielded compounds III, IV, V, VI which on treatment with different aryl anilines gave compounds VII, VIII, IX, X which under goes cyclisation with sulphur and iodine to give 2-[4-(10H-substituted phenothiazine-3-yl)-6-pyrimidin-2-phenylthiol/-ol/-amine/-thiol] pyrrole XI(a-j), XII(a-j), XIII(a-j) and XIV(a-j) respectively. The structural products were characterized by elemental analysis and spectral data.

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Section: Introductionmentioning

confidence: 99%