Structure-activity relationships in a series of 11-deoxy prostaglandins

Hall, Daniel; Jaitly, K.D.

doi:10.1016/0090-6980(76)90106-4

Cited by 9 publications

(2 citation statements)

References 10 publications

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“…The resulting changes in the DKD kidney include renal hemodynamic alteration, glomerular hypertension, and decrease in glomerular filtration rate ( Alicic et al, 2017 ). Prostaglandin B2 has been found to reduce mean arterial pressure and increase renal blood flow ( Marchand et al, 1973 ; Hall and Jaitly, 1976 ). In our study, prostaglandin B2 was the most elevated among all the metabolites and was positively correlated with the FBG level and negatively correlated with the ALB level.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of Serum Metabolites and Gut Microbiota in Diabetic Kidney Disease

et al. 2022

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Disturbance of circulating metabolites and disorders of the gut microbiota are involved in the progression of diabetic kidney disease (DKD). However, there is limited research on the relationship between serum metabolites and gut microbiota, and their involvement in DKD. In this study, using an experimental DKD rat model induced by combining streptozotocin injection and unilateral nephrectomy, we employed untargeted metabolomics and 16S rRNA gene sequencing to explore the relationship between the metabolic profile and the structure and function of gut microbiota. Striking alterations took place in 140 serum metabolites, as well as in the composition and function of rat gut microbiota. These changes were mainly associated with carbohydrate, lipid, and amino acid metabolism. In these pathways, isomaltose, D-mannose, galactonic acid, citramalic acid, and prostaglandin B2 were significantly upregulated. 3-(2-Hydroxyethyl)indole, 3-methylindole, and indoleacrylic acid were downregulated and were the critical metabolites in the DKD model. Furthermore, the levels of these three indoles were restored after treatment with the traditional Chinese herbal medicine Tangshen Formula. At the genera level, g_Eubacterium_nodatum_group, g_Lactobacillus, and g_Faecalibaculum were most involved in metabolic disorders in the progression of DKD. Notably, the circulating lipid metabolites had a strong relationship with DKD-related parameters and were especially negatively related to the mesangial matrix area. Serum lipid indices (TG and TC) and UACR were directly associated with certain microbial genera. In conclusion, the present research verified the anomalous circulating metabolites and gut microbiota in DKD progression. We also identified the potential metabolic and microbial targets for the treatment of DKD.

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Section: Discussionmentioning

confidence: 99%

Characteristics of Serum Metabolites and Gut Microbiota in Diabetic Kidney Disease

et al. 2022

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“…The best-characterized oxylipins are the ones derived from AA, and so far, the levels of AA-derived oxylipins in plasma have shown detrimental effects on cardiovascular health. Oxylipins derived from arachidonic acid promote inflammation [69,70], oxidative stress [71], and vasoconstriction [71,72]. The very first product of COX-induced oxidation of AA is prostaglandin G2 (PGG2) and subsequently, prostaglandin H2 (PGH2) which is further converted to other PGs and thromboxanes through PG and thromboxane synthase [73].…”

Section: Polyunsaturated Fatty Acids In Atherosclerosismentioning

confidence: 99%

Overcoming the Bitter Taste of Oils Enriched in Fatty Acids to Obtain Their Effects on the Heart in Health and Disease

et al. 2019

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Fatty acids come in a variety of structures and, because of this, create a variety of functions for these lipids. Some fatty acids have a role to play in energy metabolism, some help in lipid storage, cell structure, the physical state of the lipid, and even in food stability. Fatty acid metabolism plays a particularly important role in meeting the energy demands of the heart. It is the primary source of myocardial energy in control conditions. Its role changes dramatically in disease states in the heart, but the pathologic role these fatty acids play depends upon the type of cardiovascular disease and the type of fatty acid. However, no matter how good a food is for one’s health, its taste will ultimately become a deciding factor in its influence on human health. No food will provide health benefits if it is not ingested. This review discusses the taste characteristics of culinary oils that contain fatty acids and how these fatty acids affect the performance of the heart during healthy and diseased conditions. The contrasting contributions that different fatty acid molecules have in either promoting cardiac pathologies or protecting the heart from cardiovascular disease is also highlighted in this article.

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Synthesis and gastrointestinal pharmacology of some 15- and 16- modified (±)-11-deoxyprostaglandins

et al. 1978

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Structure-activity relationships in a series of 11-deoxy prostaglandins

Cited by 9 publications

References 10 publications

Characteristics of Serum Metabolites and Gut Microbiota in Diabetic Kidney Disease

Characteristics of Serum Metabolites and Gut Microbiota in Diabetic Kidney Disease

Overcoming the Bitter Taste of Oils Enriched in Fatty Acids to Obtain Their Effects on the Heart in Health and Disease

Synthesis and gastrointestinal pharmacology of some 15- and 16- modified (±)-11-deoxyprostaglandins

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