“…The pharmacophore model proposed in this study shares much with a number of other models which have been proposed for the GABA convulsant site (Soloway, 1965;Milbrath et al, 1979;Klunk et al, 1983;Ticku and Maksay, 1983;Ozoe and Matsumura, 1986;Matsumura et al, 1987;Wong and Andrews, 1989;Ozoe et al, 1990;Watanabe et al, 1990;Mullin, 1991;Paramonov et al, 1990;Calder et al, 1993;Lees and Calder, 1996;Akamatsu et al, 1997). There are some differences however, particularly with respect to the placement of the isopropenyl group of picrotoxinin in this model compared to the model of Akamatsu (Akamatsu eta/., 1997).…”