Structure–Activity Relationships for Side Chain Oxysterol Agonists of Hedgehog Signaling

Abstract

The stereochemistry at the 23-position for analogues 34 and 35 was reversed in the original paper. In actuality, oxysterol 34 is the 23(R) diastereomer and 35 is the 23(S) diastereomer; therefore, the data presented in Table 2 and Figures 1−3 corresponds to 23(S)-hydroxycholesterol. Below are modifications to the TOC graphic and Scheme 3.