Structure–Activity Relationships for Antioxidant Activities of a Series of Flavonoids in a Liposomal System

Arora, Arti; Nair, Muraleedharan G.; Strasburg, Gale M.

doi:10.1016/s0891-5849(97)00458-9

Cited by 491 publications

(288 citation statements)

References 27 publications

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“…These variations in results may be partially explained by the fact that effects of these compounds are dependent on usage dose, duration of use and individual metabolism. Of course, these discrepancies may also be attributable to the chemical structure of flavonoid compound, bird's age and specific responses of different species to these phytogenic compounds (Arora et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Improved performance and immunological responses as the result of dietary genistein supplementation of broiler chicks

Rasouli

Jahanian

2015

Animal

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The present study aimed to investigate the effect of supplemental genistein (an isoflavonoid) on performance, lymphoid organs' development, and cellular and humoral immune responses in broiler chicks. A total of 675-day-old male broiler chicks (Ross 308) were randomly assigned to the five replicate pens (15 chicks each) of nine experimental diets. Dietary treatments included a negative (not-supplemented) control diet, two positive control groups (virginiamycin or zinc-bacitracin, 20 mg/kg), and diets containing 10, 20, 40, 80, 160 and 320 mg/kg of genistein. The cutaneous basophil hypersensivity (CBH) test was measured at day 10 of age after toe web injection with phytohemagglutinin-P. In addition, sera samples were collected after different antigen inoculations to investigate antibody responses. At day 28 of age, three randomly selected birds from each pen were euthanized to evaluate the relative weights of lymphoid organs. Results showed that dietary supplementation of both antibiotics increased ( P < 0.01) feed intake during 1 to 42 days of age. Furthermore, daily weight gain was influenced ( P < 0.01) by dietary treatments throughout the trial, so that the birds fed on antibiotics and 20 to 80 mg/kg genistein diets revealed the greater weight gains compared with other experimental groups. The best ( P < 0.05) feed conversion ratio assigned to the birds fed on diets containing antibiotics and moderate levels (40 to 80 mg/kg) of genistein. Although the relative weights of thymus ( P < 0.05) and bursa of Fabricius ( P < 0.01) were greater in birds fed on genistein-supplemented diets compared with antibiotics-supplemented birds, the spleen weight was not affected by experimental diets. Similarly, CBH response and antibody titers against Newcastle and infectious bronchitis disease viruses were markedly ( P < 0.05) greater in chicks fed on diets supplemented with 20 to 80 mg/kg of genistein. Interestingly, the higher dosages of genistein suppressed CBH and antibody responses to the levels seen by control and antibiotics chicks. Dietary inclusion of genistein increased ( P < 0.05) lymphocytes and subsequently reduced ( P < 0.01) heterophil to lymphocyte ratio. The present findings indicate that dietary genistein supplementation at the levels of 20 to 80 mg/kg not only improves growth performance, but also could beneficially affect immunological responses in broiler chicks.Keywords: broiler chicks, genistein, humoral immunity, isoflavonoids, leukocyte subpopulations ImplicationsComparative effects of two antibiotics (virginiamycin or zincbacitracin) and supplemental genistein were assessed in broiler chicks. Results showed that the birds fed on diets containing antibiotics and 20 to 80 mg/kg of genistein had the greater weight gains. Dietary genistein supplementation increased the relative weights of thymus and bursa of Fabricius. In addition, antibody responses against viral antigens were greater in genistein-supplemented chicks compared with those on antibiotics diets. Dietary inclusion of genistein increased lymp...

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Section: Discussionmentioning

confidence: 99%

Improved performance and immunological responses as the result of dietary genistein supplementation of broiler chicks

Rasouli

Jahanian

2015

Animal

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“…Flavonoids have been deeply studied and have shown to possess innumerous biological activities from which the antioxidant properties are the best-described. [22][23][24][25][26][27] Considering the structural similarities, some of these properties are likely to be shared with 2-styrylchromones, although it needs to be experimentally confirmed. Thus, the present work consisted in studying the scavenging activities for the above-referred ROS and RNS of various 2-styrylchromone derivatives (Fig.…”

Section: Introductionmentioning

confidence: 99%

2-Styrylchromones: Novel strong scavengers of reactive oxygen and nitrogen species

Gomes

Fernandes

Silva

et al. 2007

Bioorganic & Medicinal Chemistry

127

173

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Abstract-2-Styrylchromones are a small group of naturally occurring chromones, vinylogues of flavones (2-phenylchromones). Natural and synthetic 2-styrylchromones have been tested in different biological systems, showing activities with potential therapeutic applications. In particular, the potential and hitherto understudied antioxidant behavior of these compounds has been raised as a matter of interest. Thus the present work consisted in the study of the in vitro scavenging activities for reactive oxygen species (ROS) and reactive nitrogen species (RNS) of various 2-styrylchromone derivatives and structurally similar flavonoids. Some of the studied 2-styrylchromones proved to be extremely efficient scavengers of the different ROS and RNS, showing, in some cases, IC 50 s under 1 lM. The hydroxylation pattern of 2-styrylchromones, especially in the B-ring but also in the A ring, modulates the activity of these compounds, the catecholic derivatives being the most effective scavengers. The styryl pattern also contributes to their observed outstanding antioxidant activity. In conclusion, the scavenging activities for ROS/RNS of 2-styrylchromone derivatives, here shown for the first time, provide novel and most promising compounds to be applied as antioxidants.

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“…Nascimento (2006) fez o estudo químico de frações do extrato benzeno:etéreo das folhas de S. stipulaceum detectou a presença de flavonoides, como a quercetina e o kanferol. Por sua vez, Cao et al (1997) e Arora et al (1998) destacam que extratos de plantas podem agir como antioxidantes ou pró-oxidantes, dependendo da estrutura e composição das diferentes classes de polifenóis presentes no extrato e da interação entre estes polifenóis.…”

Section: Resultsunclassified

A etnobotânica aplicada à úlcera gástrica e avaliação farmacológica de Solanum stipulaceum

et al. 2017

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ResumoO saber popular sobre plantas medicinais tem auxiliado estratégias de bioprospecção de espécies e direcionado o estudo para a descoberta de novas atividades farmacológicas. O objetivo desta pesquisa foi identificar espécies medicinais utilizadas contra úlcera gástrica pela comunidade do Povoado Vila Capim, Arapiraca, Alagoas e, avaliar a atividade antiulcerogênica gástrica da espécie mais saliente. Para a seleção dos informantes-chave utilizou-se a técnica da bola de neve e aplicadas entrevistas semiestruturadas. A análise das falas foi pela técnica do Discurso do Sujeito Coletivo. Para os testes farmacológicos foram utilizados ratos Wistar machos no modelo de lesão gástrica aguda induzida por etanol absoluto. A toxicidade aguda foi avaliada. Dezessete informantes-chave indicaram os sintomas e plantas medicinais utilizadas contra a úlcera gástrica. A espécie com maior valor de saliência foi a Solanum stipulaceum (sacatinga), escolhida para testes químicos e farmacológicos. O extrato aquoso bruto (SSaq) apresentou atividade significativa na dose de 200 mg kg -1 (p<0,05), sendo capaz de inibir lesões (91,35%). O extrato etanólico (SSet) demonstrou atividade gastroprotetora nas doses de 200 e 400 mg kg -1 (p<0.01), com inibição de 71,12% e 76,38%, respectivamente. É necessário aprofundar os estudos para a elucidação dos compostos químicos das folhas da espécie, toxicologia e identificação dos mecanismos de ação subjacentes à atividade gastroprotetora de S. stipulaceum.Palavras-chave: Plantas medicinais, bioprospecção, análise de saliência, ensaios in vivo. Applied ethnobotany to gastric ulcer and pharmacological evaluation of Solanum stipulaceum AbstractThe popular knowledge about medicinal plants has helped the bioprospecting strategies of species and directed to a discovery of new pharmacological activities. The aim of this study was to identify medicinal species used against gastric ulcer in the Vila Capim village, Arapiraca, Alagoas, and it evaluating a gastric anti -inflammatory activity of the most salient species. For a selection of key informants has used a snowball technique. The TCLE was signed and semi-structured interviews were applied. The analysis of the speeches was done on the Discourse of the Collective Subject technique. For pharmacological experimental tests, plant extract was underwent the Acute Gastric Lesion Model induced by absolute ethanol and using Wistar male rats. Acute toxicity was evaluated. Seventeen key informants indicated the symptoms and the medicinal plants used against gastric ulcer. The species with the highest salience value was Solanum stipulaceum Roem & Schult (sacatinga), chosen for chemical and pharmacological tests. The crude aqueous extract (SSaq) presented significant activity at a dose of 200 mg kg -1 (p<0.05), being able to inhibit lesions (91.35%). Ethanolic extract (SSet) showed gastroprotective activity at doses of 200 and 400 mg kg -1 (p <0.01), with inhibition of (71.12% and 76.38%), respectively. Further studies will be need for analysis of toxicit y and id...

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Structure–Activity Relationships for Antioxidant Activities of a Series of Flavonoids in a Liposomal System

Cited by 491 publications

References 27 publications

Improved performance and immunological responses as the result of dietary genistein supplementation of broiler chicks

Improved performance and immunological responses as the result of dietary genistein supplementation of broiler chicks

2-Styrylchromones: Novel strong scavengers of reactive oxygen and nitrogen species

A etnobotânica aplicada à úlcera gástrica e avaliação farmacológica de Solanum stipulaceum

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