Structure–Activity Relationship Studies in Benzothiadiazoles as Novel Vaccine Adjuvants
Masiel M. Belsuzarri,
Yukiya Sako,
Tyler D. Brown
et al.
Abstract:Extracellular
vesicles (EVs) can transfer antigens and immunomodulatory
molecules, and such EVs released by antigen-presenting cells equipped
with immunostimulatory functions have been utilized for vaccine formulations.
A prior high-throughput screening campaign led to the identification
of compound 634 (1), which enhanced EV release
and increased intracellular Ca2+ influx. Here, we performed
systematic structure–activity relationship (SAR) studies to
investigate the scaffold for its potency as a vaccine adjuv… Show more
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