Structure-activity relationship (SAR) studies on the mutagenic properties of 2,7-diaminofluorene and 2,7-diaminocarbazole derivatives

Achieving C(sp2)–C(sp3) Coupling with BCP-F2 Building Blocks via Barluenga Coupling: A Comparative Approach

“…Furthermore, the collaboration between Merck and Co., Inc. with the Qin lab demonstrated that the cross-coupling reaction between hydrazone 6 [Ar = 2-(1,3,5-trimethylphenyl) (Mes-), R 1 = alkyl, R 2 = H, alkyl] and alkylboronic acid 7 (R 3 = alkyl) followed by functionalization of the corresponding alkylboronic acid intermediate (not shown) can afford a diverse library of products (Scheme C) . In addition, the Barluenga coupling reaction has also been included in the synthesis of pharmaceutically active compounds …”