Structure-activity relationship of Schiff base derivatives of bis(aminophenyl)disulfide and p-vanillin as antimicrobial agents

Narain, Yasoda; Jhaumeer‐Laulloo, Sabina; Bhowon, Minu G.

doi:10.4314/ijbcs.v4i1.54232

Cited by 5 publications

(12 citation statements)

References 14 publications

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“…Compound L 1 was showed good antibacterial activity against Staphylococcus aureus as compared to standard antibiotics CTX30 and AMC30. L 1 and L 2 compounds were similar affected against Candida tropicalis and C. albi- (4). A similar study, in vitro biological screening of the synthesized Schiff-bases has been carried out against the phyto pathogenic bacteria (Azotobacter and Rhizobium) and fungi (Aspergillus niger and Fusarium oxysporium).…”

Section: Resultsmentioning

confidence: 84%

“…The Super Bug (multidrug resistant organisms) poses a significant threat to global health. Schiff bases bearing sulphur, aryl or heterocyclic groups having nitrogen are known to possess biological activities (4).Recent studies have focused on the biological, especially antitumor (5-7), antibacterial (8,9), antifungal, anti-HIV (10) properties of disulphide-Schiff bases. In vitro biological screenings of the synthesized ligands were carried out against the human pathogens.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Synthesis of disulphide-Schiff base derivatives and investigations of in vitro antimicrobial activities against some human pathogens

Durmuş

Dalmaz

Dulger

et al. 2017

The EuroBiotech Journal

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Thio-Schiff bases are becoming increasingly widespread in various branches such as the preparation of certain medicines, cosmetic products, and polymer production. In particular, the presence of antibacterial, antifungal, antiviral, antitumor and antimalarial properties of Schiff bases containing sulfur in the structure has made these compounds attractive in different disciplines. In this study, different derivatives of dimeric disulfide-Schiff bases have been synthesized. The antibacterial and antifungal activities of the synthesized these compounds were investigated in vitro against some human pathogens (Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus and Candida albicans, C. tropicalis, C. guilliermondii and C. glabrata). Test microorganisms were isolated from the patients appyling to Medical Faculty Hospital of Duzce University were used. Diffusion method was used to determine the antimicrobial activities of the compounds.standard antibacterial (Cefotaxime, Amoxicillin/clavulanicacid) and antifungal (Posaconazole) antibiotics were used as the control group and the results were compared. The result indicated that antimicrobial activity of Disulphide-Schiff Base Derivatives exhibited less activity against bacteria as compared to AMC30 (Amoxicillin/clavulanicacid), but highly effective against bacteria as compared to CTX30 (Cefotaxime). In addition, the compounds exhibited less activity against yeast.

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Section: Resultsmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Synthesis of disulphide-Schiff base derivatives and investigations of in vitro antimicrobial activities against some human pathogens

Durmuş

Dalmaz

Dulger

et al. 2017

The EuroBiotech Journal

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“…The compounds 2-aminothiophenol, benzaldehyde, 2-thiophen carbaldehyde, 3-methyl-2-thiophen carbaldehyde, 5-methyl-2thiophen carbaldehyde, sodium hydroxide and solvents were purchased from Merck(Germany), and cerium(III) nitrate hexahydrate, otolualdehyde, p-tolualdehyde were purchased from Acros (Acros Organics NJ, USA), and 2hydroxy-1-naphthaldehyde was purchased from Sigma-Aldrich (Germany), and CeO2 nanoparticles were prepared according to previous literatures [13].…”

Section: Generalmentioning

confidence: 99%

“…1 HNMR (400 MHz, CDCl3, δ): 7.19 -7.07 (m, 2H), 6.66 (dd, 1H,J = 8.5, 1.3 Hz), 6.56 (td, 1H, J = 7.5, 1.2 Hz), 4.31 (s, 2H). 13 7.65 (dd, 1H, J = 7.7, 1.5 Hz), 7.53 (d, 1H, J = 5.0 Hz), 7.51 (d, 1H, J = 3.6 Hz), 7.15 (dd, 2H, J = 7.4, 1.7 Hz), 7.12 (dd, 1H, J = 3.4, 1.4 Hz), 7.01 (dd, 1H, J = 7.4, 1.6 Hz). 13…”

Section: 2'-disulfanediyldianiline (2)mentioning

confidence: 99%

Synthesis and Characterization of Dimeric Thio-Schiff Bases by Nano Cerium Oxide and Examination of Their Antimicrobial Activities

Dalmaz

Durmuş

Dulger

et al. 2021

Sakarya University Journal of Science

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In this work, firstly, CeO2 nanoparticles, which can be used as catalysts in many reactions, were synthesized by preparing aqueous solution of cerium(III) nitrate hexahydrate in basic medium. In the second step, the synthesis of dimeric thio Schiff bases was carried out using two different methods. Effect of catalyst on some parameters such as reaction time and yield of product were investigated. The antimicrobial activities of the ligands have been screened in vitro against the organisms Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae (Gram negative bacteria), Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Bacillus cereus (Gram positive bacteria) and Candida albicans, C. tropicalis, C. guilliermondii, C. glabrata by Disc Diffusion and Microdilution methods. At the same time, antimicrobial activities of ligands were compared to standard antibiotics (Cefotaxime, Amoxicillin/clavulanic acid, Posacanazole, Nystatin and Gentamicin). Generally, the results obtained in this research showed that all tested ligands exhibited more effect towards Gram positive bacteria and Candida species as compared to standard antibiotics.

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“…e high antimicrobial activity of the [(AMMP) 2 (DHBQ)] complex can be attributed to the presence of both pyrimidine and p-benzoquinone rings, which are known for their biological activities [55,56]. Furthermore, it has been reported in the literature that heterocyclic compounds with electron-donating methoxy group substituents at the para position of the aromatic rings exhibit excellent antimicrobial activity [57][58][59].…”

Section: Antimicrobial Activity Studiesmentioning

confidence: 99%

Synthesis, Characterization, and Biological Evaluation of a New Hydrogen-Bonded Charge-Transfer Complex of 2-Amino-4-methoxy-6-methylpyrimidine

Alghanmi

2019

Journal of Chemistry

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A new hydrogen-bonded charge-transfer (HB-CT) complex formed between the donor 2-amino-4-methoxy-6-methylpyrimidine (AMMP) and the π-acceptor 2,5-dihydroxy-p-benzoquinone (DHBQ) was investigated in both solid and solution states. The investigation was conducted using UV-Vis, CHN, FTIR, 1H NMR, XRD, and TG-DTA analyses. The molecular composition of the CT complex in MeOH was found to be 1 : 1. The formation constant (KCT), molecular extinction coefficient (ε), and several other spectroscopic physical parameters were evaluated at different temperatures. The thermodynamic properties of the CT interaction in MeOH were studied by calculating the enthalpy (ΔH°), entropy (ΔS°), and free energy (ΔG°). The thermodynamic parameters indicated that van der Waals interactions and hydrogen bonding occur between AMMP and DHBQ in MeOH. The CHN, FTIR, and TG-DTA measurements confirmed that the solid HB-CT complex forms in a 2 : 1 ratio, i.e., [(AMMP)2(DHBQ)], and exhibits high stability. Moreover, XRD analysis was used to establish that the mean particle size of the complex is 23 nm. Finally, the solid HB-CT complex was screened for its antibacterial, antifungal, and antioxidant activities. It shows good activity against various bacterial and fungal species. Furthermore, the HB-CT complex exhibits good DPPH scavenging activity.

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Structure-activity relationship of Schiff base derivatives of bis(aminophenyl)disulfide and p-vanillin as antimicrobial agents

Cited by 5 publications

References 14 publications

Synthesis of disulphide-Schiff base derivatives and investigations of in vitro antimicrobial activities against some human pathogens

Synthesis of disulphide-Schiff base derivatives and investigations of in vitro antimicrobial activities against some human pathogens

Synthesis and Characterization of Dimeric Thio-Schiff Bases by Nano Cerium Oxide and Examination of Their Antimicrobial Activities

Synthesis, Characterization, and Biological Evaluation of a New Hydrogen-Bonded Charge-Transfer Complex of 2-Amino-4-methoxy-6-methylpyrimidine

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