Structure-activity relationship of carbon nitride dots in inhibiting Tau aggregation

Zhou, Yiqun; Kandel, Nabin; Bartoli, Mattia; Serafim, Leonardo F.; ElMetwally, Ahmed E.; Falkenberg, Sophia M.; Paredes, Xavier E.; Nelson, Christopher J.; Smith, Nathan; Padovano, Elisa; Zhang, Wei; Mintz, Keenan J.; Ferreira, Braulio C.L.B.; Cilingir, Emel Kirbas; Chen, Jiuyan; Shah, Sujit Kumar; Prabhakar, Rajeev; Tagliaferro, Alberto; Wang, Qianqian

doi:10.1016/j.carbon.2022.03.021

Cited by 22 publications

(34 citation statements)

References 72 publications

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“…The most common approach for fractionalization of CDs is chromatography . In our previous studies, many chromatographic techniques including reversed-phase column, thin-layer, and size-exclusion chromatography (SEC) were employed to separate CDs into different fractions based on their differences in hydrophilicity and particle size. , It is worth noting that most CDs applied were hydrophilic or amphiphilic, so whether column or thin-layer chromatography, reversed phase was applied. The developing solvents are usually more polar than those used for normal-phase counterparts.…”

Section: Fractionalization Of Carbon Dotsmentioning

confidence: 99%

“…Combination of these results with FTIR and X-ray photoelectron spectroscopies, mass spectrometry, TGA, and atomic force and transmission electron microscopies presented three well-defined structural models as illustrated in Figure with a distribution of structures in virtual samples. These structural models have laid foundations for a recent molecular dynamic simulation study on the interactions between CNDs and microtubule-associated protein tau, whose aggregation is a hallmark of Alzheimer’s disease (AD). In addition, these CD structural models are currently applied to study a CO 2 uptake hypothesis for an enhanced photosynthesis with Y-CDs previously reported by our group .…”

Section: Structures Of Carbon Dotsmentioning

confidence: 99%

“…However, under abnormal conditions, MAPT will undergo misfolding and aggregation, and MAPT aggregates can further lead to the aggregation of normal soluble tau proteins in recipient cells, which results in the propagation of tau pathology in a prion-like manner . Our group recently found the aforementioned CNDs could inhibit MAPT aggregation and ROS without causing any toxicity . With CNDs fractionalized into five fractions, the MAPT aggregation inhibition was observed with relatively hydrophobic fractions.…”

Section: Carbon Dots In Nanomedicinementioning

confidence: 99%

Section: Carbon Dots In Nanomedicinementioning

confidence: 99%

“…14,55 Most significantly, fractionalization is often applied to elucidate basic principles in the properties of CDs such as PL and various structure−property relationships. 14,55 The most common approach for fractionalization of CDs is chromatography. 56 In our previous studies, many chromatographic techniques including reversed-phase column, thinlayer, and size-exclusion chromatography (SEC) were employed to separate CDs into different fractions based on their differences in hydrophilicity and particle size.…”

Section: ■ Introductionmentioning

confidence: 99%

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Structure–Property–Activity Relationships in Carbon Dots

2022

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Carbon dots (CDs) are one of the most versatile nanomaterials discovered in the 21st century. They possess many properties and thus hold potentials in diverse applications. While an increasing amount of attention has been given to these novel nanoparticles, the broad scientific community is actively engaged in exploring their limits. Recent studies on the fractionalization and assembly of CDs further push the limits beyond just CDs and demonstrate that CDs are both a mixture of heterogeneous fractions and promising building blocks for assembly of large carbon-based materials. With CDs moving forward toward both microscopic and macroscopic levels, a good understanding of the structure−property−activity relationships is essential to forecasting the future of CDs. Hence, in this Perspective, structure−property− activity relationships are highlighted based on the repeatedly verified findings in CDs. In addition, studies on CD fractionalization and assembly are briefly summarized in this Perspective. Eventually, these structure−property−activity relationships and controllability are essential for the development of CDs with desired properties for various applications especially in photochemistry, electrochemistry, nanomedicine, and surface chemistry. In summary, in our opinion, since 2004 until the present, history has witnessed a great development of CDs although there is still some room for more studies. Also, considering many attractive properties, structure−property−activity relationships, and the building block nature of CDs, a variety of carbon-based materials of interest can be constructed from CDs with control. They can help reduce blind trials in the development of carbon-based materials, which is of great significance in materials science, chemistry, and any fields related to the applications.

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Section: Fractionalization Of Carbon Dotsmentioning

confidence: 99%

Section: Structures Of Carbon Dotsmentioning

confidence: 99%

Section: Carbon Dots In Nanomedicinementioning

confidence: 99%

Section: Carbon Dots In Nanomedicinementioning

confidence: 99%