Structurally Interesting Diarymethane Derivatives from Securidaca inappendiculata

Abstract

Summary of main observation and conclusionSecurines A—E, three dimeric diarymethane derivatives (1—3) and two enantiomeric diarymethane derivative monomers (4 and 5), were isolated and characterized from the medicinal plant Securidaca inappendiculata. Compounds 1 and 2 are a pair of enantiomeric diarymethane derivative dimers, and compound 3 is a mesomeric diarymethane derivative dimer. Their structures were determined by a combination of spectroscopic data, X‐ray crystallography, electronic circular dichroism (ECD) analysis, and computational ECD calculations. Dimeric compounds 1—3 showed moderate antiplasmodial activities with IC50 values of 0.9, 1.4, and 1.5 μM, respectively.

Cephalotane‐Type Norditerpenoids from Cephalotaxus fortunei var. alpina

“…alpine by us. As our continuing efforts to explore new antiplasmodial agents from natural products, [ 27‐29 ] compounds 8 , 10 , and 11 were selectively tested for antimalaria activity against Plasmodium falciparum strain Dd2 (resistant to chloroquine, pyrimethamine, and mefloquine) using an SYBR‐Green I assay, [ 30‐31 ] with artemisinin as the positive control (IC 50 = 13 ± 0.9 nmol/L). Compounds 10 and 11 exhibited moderate inhibitory effects with IC 50 values of 3.9 ± 0.9 and 10.3 ± 1.8 μmol/L, respectively.…”

“…The antiplasmodial activity was measured using an SYBR‐ Green I assay against Plasmodium falciparum strain Dd2 with artemisinin as the positive control according to the previously reported method. [ 30‐31 ]…”

Sesquiterpenoids and Cytochalasins with Immunosuppressive Activity from Sonchus wightianus

“…Extraction and isolation procedures were carried out according to previously reported methods [26–30] . Specifically, the air‐dried and powdered whole plants of S. wightianus (3 kg) were soaked with 95 % EtOH (20 L×3) to give a residue (350 g), which was suspended in warm water followed by extraction with EtOAc.…”

Cephalotane-type C20diterpenoids fromCephalotaxus fortuneivar.alpina

“…alpina. 8 With our continuing efforts to explore new antiplasmodial agents from natural products, 5,[24][25][26][27][28] all the compounds were tested for antimalarial activity against the Plasmodium falciparum strain Dd2 (resistant to chloroquine, pyrimethamine, and mefloquine) using an SYBR-Green I assay, with artemisinin as the positive control. The results (Table 8) showed that no compound exhibited more than 41% inhibition at 1 μM.…”