Structurally different anabolic androgenic steroids reduce neurite outgrowth and neuronal viability in primary rat cortical cell cultures

Zelleroth, Sofia; Nylander, Erik; Örtenblad, Axel; Stam, Frida; Nyberg, Fred; Grönbladh, Alfhild; Hallberg, Mathias

doi:10.1016/j.jsbmb.2021.105863

Cited by 14 publications

(7 citation statements)

References 62 publications

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“… 32 Neural alterations likely play a role in the common mental health problems in patients with high androgen levels. 33 The total cerebral cortex volume of people with high androgen levels was more compact than that of controls. 34 A trophy of the cerebral cortex is a risk factor.…”

Section: Discussionmentioning

confidence: 95%

Clinical Characteristics of Hyperandrogenism Include Hirsutism, Polycystic Ovary Syndrome, and Acne: Association with Psychiatric Disease in Women -A Nationwide Population-Based Cohort Study in Taiwan

Wang¹,

Chou²,

Lee³

et al. 2022

IJWH

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Objective Previous studies have shown an increased in psychiatric disorders in women with disorders associated with hyperandrogenism, but few nationwide cohorts have studied this phenomenon. Therefore, this study is aimed to examine the association between the clinical manifestations of hyperandrogenism and subsequent psychiatric disorders. Methods Based on the National Health Insurance Research Database, 49,770 enrolled participants were matched for age and index date between January 1, 2000, and December 31, 2015. Hirsutism, polycystic ovary syndrome, and acne are characterized by hyperandrogenism. After adjusting for confounding factors, we used Cox proportional analysis to compare the risk of psychiatric disorders during the 16 years of follow-up. Results Of all the participants, 1319 (13.25%) had psychiatric disorders in the study group, whereas only 3900(9.80%) had psychiatric disorders in the control group. After adjusting for age, and monthly income, the Cox regression analysis showed that the study patients were more likely to develop psychiatric disorders (hazard ratio [HR]: 2.004, 95% confidence interval [CI] = 1.327–2.724, P < 0.001). The results demonstrated that women aged 20–29 years had a more significant risk. Conclusion Women with clinical characteristics of hyperandrogenism have a higher risk of developing psychiatric disorders, especially those aged 20–29 years.

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Section: Discussionmentioning

confidence: 95%

Clinical Characteristics of Hyperandrogenism Include Hirsutism, Polycystic Ovary Syndrome, and Acne: Association with Psychiatric Disease in Women -A Nationwide Population-Based Cohort Study in Taiwan

Wang¹,

Chou²,

Lee³

et al. 2022

IJWH

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“… Person et al, 2017 also observed the strongest βIII-tubulin staining in testicular tissue in the spermatogenic cells, stem cells that give rise to sperm cells ( Person et al, 2017 ), supporting the notion of TUBB3 being involved with spermatogenesis ( De Gendt et al, 2011 ). In contrast, treating rat primary cortical neurons with supra-physiological doses of testosterone failed to elevate Tubb3 expression, despite the strong expression of the androgen receptor in the same cells ( Zelleroth et al, 2021 ).…”

Section: Introductionmentioning

confidence: 91%

βIII-Tubulin Gene Regulation in Health and Disease

Duly

Kao

Teo

et al. 2022

Front. Cell Dev. Biol.

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Microtubule proteins form a dynamic component of the cytoskeleton, and play key roles in cellular processes, such as vesicular transport, cell motility and mitosis. Expression of microtubule proteins are often dysregulated in cancer. In particular, the microtubule protein βIII-tubulin, encoded by the TUBB3 gene, is aberrantly expressed in a range of epithelial tumours and is associated with drug resistance and aggressive disease. In normal cells, TUBB3 expression is tightly restricted, and is found almost exclusively in neuronal and testicular tissues. Understanding the mechanisms that control TUBB3 expression, both in cancer, mature and developing tissues will help to unravel the basic biology of the protein, its role in cancer, and may ultimately lead to the development of new therapeutic approaches to target this protein. This review is devoted to the transcriptional and posttranscriptional regulation of TUBB3 in normal and cancerous tissue.

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“…There are few doubts about the danger the use of anabolizers may carry for the cardiovascular system [ 464 , 465 ] and the brain [ 466 ], including behavioral and psychiatric disorders [ 467 ], but also extreme musculation, metabolically distorting bodybuilding [ 313 ], and obviously, alterations of the sexual (and reproductive) functions [ 468 , 469 ]. The extended lack of differentiation between androgen classes may be, in part, a justification for the confuse hoarding of all androgens in a single group of anabolic hormones (or anabolic drugs).…”

Section: Current Pharmacological Utilization Of Androgensmentioning

confidence: 99%

The Roles of Androgens in Humans: Biology, Metabolic Regulation and Health

Alemany

2022

IJMS

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Androgens are an important and diverse group of steroid hormone molecular species. They play varied functional roles, such as the control of metabolic energy fate and partition, the maintenance of skeletal and body protein and integrity and the development of brain capabilities and behavioral setup (including those factors defining maleness). In addition, androgens are the precursors of estrogens, with which they share an extensive control of the reproductive mechanisms (in both sexes). In this review, the types of androgens, their functions and signaling are tabulated and described, including some less-known functions. The close interrelationship between corticosteroids and androgens is also analyzed, centered in the adrenal cortex, together with the main feedback control systems of the hypothalamic–hypophysis–gonads axis, and its modulation by the metabolic environment, sex, age and health. Testosterone (T) is singled out because of its high synthesis rate and turnover, but also because age-related hypogonadism is a key signal for the biologically planned early obsolescence of men, and the delayed onset of a faster rate of functional losses in women after menopause. The close collaboration of T with estradiol (E2) active in the maintenance of body metabolic systems is also presented Their parallel insufficiency has been directly related to the ravages of senescence and the metabolic syndrome constellation of disorders. The clinical use of T to correct hypoandrogenism helps maintain the functionality of core metabolism, limiting excess fat deposition, sarcopenia and cognoscitive frailty (part of these effects are due to the E2 generated from T). The effectiveness of using lipophilic T esters for T replacement treatments is analyzed in depth, and the main problems derived from their application are discussed.

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Structurally different anabolic androgenic steroids reduce neurite outgrowth and neuronal viability in primary rat cortical cell cultures

Cited by 14 publications

References 62 publications

Clinical Characteristics of Hyperandrogenism Include Hirsutism, Polycystic Ovary Syndrome, and Acne: Association with Psychiatric Disease in Women -A Nationwide Population-Based Cohort Study in Taiwan

Clinical Characteristics of Hyperandrogenism Include Hirsutism, Polycystic Ovary Syndrome, and Acne: Association with Psychiatric Disease in Women -A Nationwide Population-Based Cohort Study in Taiwan

βIII-Tubulin Gene Regulation in Health and Disease

The Roles of Androgens in Humans: Biology, Metabolic Regulation and Health

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