Structurally Controlled Bio‐hybrid Materials Based on Unidirectional Association of Anisotropic Microparticles with Human Endothelial Cells

Abstract

Biocompatible anisotropic polymer particles with bipolar affinity towards human endothelial cells are a novel type of building blocks for microstructured bio-hybrid materials. Functional polarity due to two biologically distinct hemispheres has been achieved by synthesis of anisotropic particles via electro-hydrodynamic co-jetting of two different polymer solutions and subsequent selective surface modification.

Patchiness of Embedded Particles and Film Stiffness Control Through Concentration of Gold Nanoparticles

“…[12] Methods for preparing Janus particles can be divided into direct chemical synthesis, chemical modification of particles at biphasic interfaces and topographically selective modification of particles. [13][14][15] Janus particles were prepared by microfluidics, [16] wet-chemical synthesis, [16,17] plasma polymerization [18] or electrohydrodynamic co-jetting, [11,15] and are limited by the choice of materials suitable for these techniques. Such a limitation can be overcome by topographically selective modification, allowing for versatile surface composition.…”

Porous polymer particles—A comprehensive guide to synthesis, characterization, functionalization and applications

“…Although there are numerous studies on CuAAC functionalization of nonporous polymers [280,298,328,[336][337][338][339][340][341][342][343][344][345][346][347][348][349][350][351], silica [352][353][354] and metal particles [355], the amount of publications on porous polymer particles is limited. Finn et al [356] described the click functionalization of a commercial porous agarose resin for affinity chromatography.…”

“…One way is analyzing microscopy images via various available software [218,241], which will also calculate the average size. Light scattering [278][279][280] and electrical sensing zone (also called Coulter counter) [45,[281][282] are rather sensitive instrument-based methods to determine size and size distribution. Microscopy and image analysis combination can be considered as the easiest method.…”

Ordered arrays of pumpkin-shaped Janus particles with tailored surface morphologies via microcontact hot embossing

“…Compared to spherical symmetric particles, anisotropic particles have distinct physical and/or chemical properties because of their broken symmetry, which are also widely observed in organisms (e.g., proteins, lipids, and self-organized superstructures) [4]. As one important class of anisotropic particles, Janus particles, which were named after the ancient Roman god Janus [5], have distinct properties on opposing sides, endowing themselves with amphiphilic behavior [6], catalytic activity [7], magnetic response [8,9], localization and rotation in electric fields [10], cell targeting [11], etc.…”