Structurally characterized zinc complexes of flavonoids chrysin and quercetin with antioxidant potential

Halevas, Eleftherios; Mavroidi, Barbara; Pelecanou, Maria; Hatzidimitriou, Antonios G.

doi:10.1016/j.ica.2021.120407

Cited by 36 publications

(50 citation statements)

References 52 publications

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“…According to Nijveldt et al, flavonoids exhibit strong cell protection against ROS through different working mechanisms including an increase in the function of endogenous antioxidants ( 46 ). First, flavonoids can work as direct radical scavengers being oxidized by radicals because of the high reactivity of the OH group of the flavonoids; hence a radical molecule becomes more stable and inactive; an example of these are rutin ( 48 ), luteolin, and quercetin ( 49 , 50 ); all of them are found in this study. Second, NO · plays a significant role in molecular events involved in neurodegenerative diseases, promoting neuronal death through oxidative damage on cellular lipids, proteins, and ADN ( 51 ); therefore, flavonoids are able to remove the overconcentration of NO · radicals ( 46 , 52 , 53 ).…”

Section: Resultsmentioning

confidence: 68%

Neuroprotective Potential of Tamarillo (Cyphomandra betacea) Epicarp Extracts Obtained by Sustainable Extraction Process

et al. 2021

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Tamarillo (Cyphomandra betacea (Cav.) Sendt.), or tree tomato, is a tropical fruit from the Andean region of South America; it is highly rich in vitamins, minerals, and polyphenolic compounds. In this study, extracts from tamarillo epicarp (TE) were obtained by pressurized liquid extraction (PLE), and their in-vitro neuroprotective potential was assessed. A central composite design with response surface methodology was performed to optimize PLE as a function of solvent composition and temperature. Selected response variables were extraction yield, total phenolic content (TPC), total flavonoid content (TFC), total carotenoid content (TCC), antioxidant (ABTS), and anti-inflammatory (LOX) activities, and anti-acetylcholinesterase (AChE) inhibitory capacity. According to the desirability function, the optimal conditions were 100% ethanol and 180°C with a 0.87 desirability value. Next, the anti-butyrylcholinesterase enzyme (BChE), reactive oxygen species (ROS), and reactive nitrogen species (RNS) inhibition as well as cytotoxicity in HK-2, THP-1 monocytes, and SH-5YSY neuroblastoma cell lines were studied for the TE extract obtained under optimized conditions. The optimum TE extract provided the following results: extraction yield (36.25%), TPC (92.09 mg GAE/g extract), TFC (4.4 mg QE/g extract), TCC (107.15 mg CE/g extract), antioxidant capacity (ABTS, IC50 = 6.33 mg/ml extract), LOX (IC50 = 48.3 mg/ml extract), and AChE (IC50 = 97.46 mg/ml extract), and showed no toxicity at concentration up to 120 μg/ml extract for all the tested cell lines. Finally, chemical characterization by liquid chromatography-tandem mass spectrometry (UHPLC-q-TOF-MS/MS) of the optimum TE extract exhibited an important presence of hydroxycinnamic acid derivatives and other phenolic acids as well as quercetin hexoside and rutin, as main metabolites responsible for the observed biological properties. All these results suggested that TE, which represents between 8 and 15% of the total fruit, could become a promising natural by-product with a potential “multitarget” activity against Alzheimer's disease.

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Section: Resultsmentioning

confidence: 68%

Neuroprotective Potential of Tamarillo (Cyphomandra betacea) Epicarp Extracts Obtained by Sustainable Extraction Process

et al. 2021

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“…According to Nijveldt et al, flavonoids exhibit strong cell protection against ROS through different working mechanisms including an increase in the function of endogenous antioxidants (46). First, flavonoids can work as direct radical scavengers being oxidized by radicals because of the high reactivity of the OH group of the flavonoids; hence a radical molecule becomes more stable and inactive; an example of these are rutin (48), luteolin, and quercetin (49,50); all of them are found in this study. Second, NO • plays a significant role in molecular events involved in neurodegenerative diseases, promoting neuronal death through oxidative damage on cellular lipids, proteins, and ADN (51); therefore, flavonoids are able to remove the overconcentration of NO • radicals (46,52,53).…”

Section: Effect Of Extraction Conditions On Abts Lox and Ache Activities Correlation With Tpc Tfc And Tcc Antioxidant Activitysupporting

confidence: 55%

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“…Therefore, it can be concluded that malic acid, chlorogenic acid, epigallocatechin gallate, quercetin, ellagic acid, and pyrogallol are the chief phenolic compounds that might be accountable for the observed antioxidant potential of the selected plant. In other studies, it has been reported that these compounds, chlorogenic acid [30], epigallocatechin gallate [31], quercetin [32], ellagic acid [33], pyrogallol [34] have potent antioxidant effects. A total of 273 compounds are reported from the seven Alnus species (A. japonica, A. hirsuta, A. glutinosa, A. incana, A. nepalensis, A. sieboldiana and A. firma), with very little or no attention being paid to alternative folks uses of those plants.…”

Section: Discussionmentioning

confidence: 99%

HPLC Characterization of Phytochemicals and Antioxidant Potential of Alnus nitida (Spach) Endl.

et al. 2021

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Antioxidants isolated from plants have attracted the interest of clinicians and common people to be used for systemic uses rather than synthetic antioxidants because of their active role in maintaining human health with minimal side effects. Alnus nitida (Spach) Endl. is an important medicinal plant native to western Himalaya and is widely distributed throughout Pakistan. The present study evaluates the phytochemical composition of this plant using HPLC along with the total content of phenolics and flavonoids. The antioxidant activities were determined following the Brand William assay. The methanolic extract (Met. Ext) of leaves, stem bark, seeds, and roots of A. nitida were used to scavenge synthetic free radicals such as DPPH and ABTS. From HPLC fingerprinting of the A. nitida selected portion, six possible phytochemicals were confirmed. Among the identified phytochemicals, there are six compounds (malic acid, chlorogenic acid, epigallocatechin gallate, quercetin, ellagic acid and pyrogallol) in the leaves of A. nitida, three (epigallocatechin gallate, ellagic acid, and pyrogallol) in the stem bark, six in the seeds (malic acid, vitamin C, epigallocatechin gallate, quercetin, ellagic acid, and pyrogallol), and five (malic acid, epigallocatechin gallate, quercetin, and ellagic acid) in root. Comparatively, the highest antioxidant potentials were recorded for the leaves extract (IC50 of 340 and 645 µg/mL against DPPH and ABTS, respectively). The percentages of inhibition were compared with the positive control ascorbic acid, which produced an IC50 value of 60 μg/mL each against the free radicals DPPH and ABTS. The highest phenolics (43.81 mg GAE/g sample) were found in the roots, while the highest flavonoid contents (53.25 mg QE/g sample) were in the leaves. It was assumed that observed antioxidant potentials of the tested plant might be due to their phytochemicals confirmed through HPLC, and thus, this plant may be a valuable candidate in treating oxidative stress and related disorders. However, further investigations are needed to isolate responsible components in pure from. Furthermore, toxicological effects in in vivo animal models are also needed to confirm the results observed in this study.

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Structurally characterized zinc complexes of flavonoids chrysin and quercetin with antioxidant potential

Cited by 36 publications

References 52 publications

Neuroprotective Potential of Tamarillo (Cyphomandra betacea) Epicarp Extracts Obtained by Sustainable Extraction Process

Neuroprotective Potential of Tamarillo (Cyphomandra betacea) Epicarp Extracts Obtained by Sustainable Extraction Process

Data_Sheet_1.pdf

HPLC Characterization of Phytochemicals and Antioxidant Potential of Alnus nitida (Spach) Endl.

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