Structural vulnerability in EPCR suggests functional modulation
Elena Erausquin,
Adela Rodríguez-Fernández,
Luis Ángel Rodríguez-Lumbreras
et al.
Abstract:The endothelial protein C receptor (EPCR) is a fundamental component of the vascular system in mammals due to its contribution in maintaining blood in a non-prothrombotic state, which is crucial for overall life development. It accomplishes this by enhancing the conversion of protein C (PC) into the anticoagulant activated protein C (APC), with this property being dependent on a known EPCR conformation that enables direct interaction with PC/APC. In this study, we report a previously unidentified conformation … Show more
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