Structural, Volumetric, and Thermodynamic Characterization of a Micellar Sphere-to-Rod Transition

Heerklotz, Heiko; Tsamaloukas, Alekos; Kita-Tokarczyk, Katarzyna; Strunz, Pavel; Gutberlet, Thomas

doi:10.1021/ja045525w

Cited by 69 publications

(80 citation statements)

References 54 publications

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“…77,92,[94][95][96] Alpha provides information concerning the flexibility, relative volume fluctuations, macromolecule solvation, and accessible surface area of proteins. A large value of a may indicate a larger magnitude of volume fluctuations, enthalpy fluctuations or both.…”

Section: Protein Flexibility and Physical Stability Effects Of Tempermentioning

confidence: 99%

“…In almost all cases, a decreases as a function of temperature before the transition midpoint of thermal unfolding with the slope of a(T) reflecting the degree of hydration. Alpha has been shown to both increase 77,94,95 or decrease 93,96 dramatically at the transition midpoint of thermal unfolding. High coefficients of thermal expansion and their decrease as a function of temperature are thought to indicate the presence of numerous structure breaking hydrophilic side chains on the surface of proteins.…”

Section: Protein Flexibility and Physical Stability Effects Of Tempermentioning

confidence: 99%

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The Complex Inter-Relationships Between Protein Flexibility and Stability

Kamerzell¹,

Middaugh²

2008

Journal of Pharmaceutical Sciences

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Section: Protein Flexibility and Physical Stability Effects Of Tempermentioning

confidence: 99%

Section: Protein Flexibility and Physical Stability Effects Of Tempermentioning

confidence: 99%

The Complex Inter-Relationships Between Protein Flexibility and Stability

Kamerzell¹,

Middaugh²

2008

Journal of Pharmaceutical Sciences

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“…The concentration-dependent changes in enthalpy were measured for myristyl maltoside using ITC at various temperatures. 148 The micelles dissociated on injection into the ITC cell until a CMC was obtained. This resulted in an isotherm with a 'quasi-sigmoidal' curve.…”

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confidence: 99%

Survey of the year 2004: literature on applications of isothermal titration calorimetry

Ababou

Ladbury

2005

J of Molecular Recognition

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The market for commercially available isothermal titration calorimeters continues to grow as new applications and methodologies are developed. Concomitantly the number of users (and abusers) increases dramatically, resulting in a steady increase in the number of publications in which isothermal titration calorimetry (ITC) plays a role. In the present review, we will focus on areas where ITC is making a significant contribution and will highlight some interesting applications of the technique. This overview of papers published in 2004 also discusses current issues of interest in the development of ITC as a tool of choice in the determination of the thermodynamics of molecular recognition and interaction.

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“…The transition can also occur upon additions of salt [81], or increasing the temperature [82] since these decrease the hydrophilic area of the surfactants due to dehydration of the PEO chains.…”

Section: Sphere-to-rod Transitionmentioning

confidence: 99%

Mesoporous Building Blocks: Synthesis and Characterization of Mesoporous Silica Particles and Films

Björk¹

2013

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On the cover, the structure of SBA-15 is illustrated. Inside the pores SEM micrographs have been inserted showing (clockwise from the top): rods, fibers, a film consisting of rods grown on a substrate, a film consisting of platelets grafted on a substrate, short rods, and platelets. In the center the sheet morphology is presented.© Emma Björk, unless otherwise stated.ISBN: 978-91-7519-516-2 ISSN: 0345-7524 Printed by LiU-tryck, Linköping, Sweden, 2013 Research is formalized curiosity. It is poking and prying with a purposeZora Neale Hurston (1903Hurston ( -1960 i ABSTRACTCatalyst supports, drug delivery systems, hosts for nanoparticles, and solar cells are just some examples of the wide range of exciting applications for mesoporous silica. In order to optimize the performance of a specific application, controlling the material's morphology and pore size is crucial. For example, short and separated particles are beneficial for drug delivery systems, while for molecular sieves, the pore size is the key parameter.In this thesis, mesoporous silica building blocks, crystallites, with hexagonally ordered cylindrical pores were synthesized, with the aim to understand how the synthesis parameters affect the particle morphology and pore size. The synthesis of the particles is performed using a sol-gel process, and in order to increase the pore size, a combination of low temperature, and additions of heptane and NH 4 F was used. By variations in the amounts of reagents, as well as other synthesis conditions, the particle morphology and pore size could be altered. Separated particles were also grown on or attached to substrates to form films. Also, a material with spherical pore structure was synthesized, for the first time using this method.It was found that a variation in the heptane concentration, in combination with a long stirring time, yields a transition between fiber and sheet morphologies. Both morphologies consist of crystallites, which for the fibers are joined end to end, while for the sheets they are attached side by side such that the pores are accessible from the sheet surface. The crystallites can be separated to a rod morphology by decreasing the stirring time and tuning the HCl concentration, and it was seen that these rods are formed within 5 min of static time, even though the pore size and unit cell parameters were evolving for another 30 min. Further studies of the effects of heptane showed that the shape and mesoscopic parameters of the rods are affected by the heptane concentration, up to a value where the micelles are fully saturated with heptane. It was also observed that the particle width increases with decreasing NH 4 F concentration, independent of heptane amount, and a platelet morphology can be formed. The formation time of the particles decrease with decreasing NH 4 F, and the growth mechanism for platelets was further studied. The pore sizes for various morphologies were altered by e.g. variations in the hydrothermal treatment conditions, or the method for removing the surfactants.ii T...

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Structural, Volumetric, and Thermodynamic Characterization of a Micellar Sphere-to-Rod Transition

Cited by 69 publications

References 54 publications

The Complex Inter-Relationships Between Protein Flexibility and Stability

The Complex Inter-Relationships Between Protein Flexibility and Stability

Survey of the year 2004: literature on applications of isothermal titration calorimetry

Mesoporous Building Blocks: Synthesis and Characterization of Mesoporous Silica Particles and Films

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