Structural Unfolding of G-Quadruplexes: From Small Molecules to Antisense Strategies
Giorgia Fracchioni,
Sabrina Vailati,
Marta Grazioli
et al.
Abstract:G-quadruplexes (G4s) are non-canonical nucleic acid secondary structures that have gathered significant interest in medicinal chemistry over the past two decades due to their unique structural features and potential roles in a variety of biological processes and disorders. Traditionally, research efforts have focused on stabilizing G4s, while in recent years, the attention has progressively shifted to G4 destabilization, unveiling new therapeutic perspectives. This review provides an in-depth overview of recen… Show more
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