Structural, thermal and antibacterial properties of polyamide 11/polymeric biocide polyhexamethylene guanidine dodecylbenzenesulfonate composites

Rogalsky, Sergiy; Bardeau, Jean‐François; Wu, Hao; Lyoshina, Lyudmila; Bulko, Olga; Tarasyuk, Oksana; Makhno, S. M.; Cherniavska, Tetiana; Kyselov, Yuriy; Koo, Joseph H.

doi:10.1007/s10853-016-0054-x

Cited by 24 publications

(23 citation statements)

References 35 publications

(70 reference statements)

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“…Poorly water-soluble PHMG salts such as PHMG stearate, PHMG sulfanilate, or PHMG dodecylbenzenesulfonate (PHMG-DBS) have been reported as efficient antimicrobial additives for polycaprolactone [34], polylactide [35], polyamides [36,37] and silicones [38]. PHMG-DBS was found to have sufficient thermal stability to be melt processed with PA-11 and PA-12 resins by conventional methods [36,37]. PA-11 films containing 5–7 wt% of PHMG-DBS showed a high activity against E. coli , as well as an excellent resistance against leaching of the polymeric biocide [37].…”

Section: Introductionmentioning

confidence: 99%

Antibiofilm Activity of Polyamide 11 Modified with Thermally Stable Polymeric Biocide Polyhexamethylene Guanidine 2-Naphtalenesulfonate

Moshynets

Bardeau

Tarasyuk

et al. 2019

IJMS

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The choice of efficient antimicrobial additives for polyamide resins is very difficult because of their high processing temperatures of up to 300 °C. In this study, a new, thermally stable polymeric biocide, polyhexamethylene guanidine 2-naphtalenesulfonate (PHMG-NS), was synthesised. According to thermogravimetric analysis, PHMG-NS has a thermal degradation point of 357 °C, confirming its potential use in joint melt processing with polyamide resins. Polyamide 11 (PA-11) films containing 5, 7 and 10 wt% of PHMG-NS were prepared by compression molding and subsequently characterised by FTIR spectroscopy. The surface properties were evaluated both by contact angle, and contactless induction. The incorporation of 10 wt% of PHMG-NS into PA-11 films was found to increase the positive surface charge density by almost two orders of magnitude. PA-11/PHMG-NS composites were found to have a thermal decomposition point at about 400 °C. Mechanical testing showed no change of the tensile strength of polyamide films containing PHMG-NS up to 7 wt%. Antibiofilm activity against the opportunistic bacteria Staphylococcus aureus and Escherichia coli was demonstrated for films containing 7 or 10 wt% of PHMG-NS, through a local biocide effect possibly based on an influence on the bacterial eDNA. The biocide hardly leached from the PA-11 matrix into water, at a rate of less than 1% from its total content for 21 days.

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Section: Introductionmentioning

confidence: 99%

Antibiofilm Activity of Polyamide 11 Modified with Thermally Stable Polymeric Biocide Polyhexamethylene Guanidine 2-Naphtalenesulfonate

Moshynets

Bardeau

Tarasyuk

et al. 2019

IJMS

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“…Cationic groups are the most widely employed as it is well known that they interact with the negatively charged bacterial membrane. In particular, functionalities such as N -halamines [ 194 , 195 , 196 ], PEIs [ 197 ], phosphonium salts [ 198 , 199 ], quaternary ammonium salts [ 200 , 201 ], and guanidines [ 202 , 203 , 204 ] are frequently used.…”

Section: Areas Of Applicationmentioning

confidence: 99%

Antimicrobial Polymers in the Nano-World

2017

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Infections are one of the main concerns of our era due to antibiotic-resistant infections and the increasing costs in the health-care sector. Within this context, antimicrobial polymers present a great alternative to combat these problems since their mechanisms of action differ from those of antibiotics. Therefore, the microorganisms’ resistance to these polymeric materials is avoided. Antimicrobial polymers are not only applied in the health-care sector, they are also used in many other areas. This review presents different strategies that combine nanoscience and nanotechnology in the polymer world to combat contaminations from bacteria, fungi or algae. It focuses on the most relevant areas of application of these materials, viz. health, food, agriculture, and textiles.

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“…Polyhexamethylene guanidine (PHMG) is a potent broad-spectrum antimicrobial that is thermally stable up to a temperature of 390 °C (both in air and argon atmosphere), which makes it a suitable candidate for thermal-initiating reactions. [21] PHMG is also commercially available at a low cost and has been widely used in water treatment, wound care, and various other consumer applications. [22] Its toxicity to humans is low, and its microbicidal effects are due to its ability to disrupt the microbial cell membrane, which is less likely to trigger drug resistance.…”

Section: Introductionmentioning

confidence: 99%

Autoclaving‐Derived Surface Coating with In Vitro and In Vivo Antimicrobial and Antibiofilm Efficacies

Zhi

Gao

et al. 2017

Adv Healthcare Materials

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Biomedical device-associated infections which engender severe threat to public health require feasible solutions. In this study, block copolymers consisting of antimicrobial, antifouling, and surface-tethering segments in one molecule are synthesized and grafted on polymeric substrates by a facile plasma/autoclave-assisted method. Hetero-bifunctional polyethylene glycol (PEG) with allyl and tosyl groups (APEG-OTs) is first prepared. PEGs with different molecular weights (1200 and 2400 Da) are employed. Polyhexamethylene guanidine (PHMG) which has excellent broad-spectrum antimicrobial activity and thermal/chemical stability, is conjugated with APEG-OTs to generate the block copolymer (APEG-PHMG). Allyl terminated PHMG (A-PHMG) without PEG segments is also synthesized by reacting PHMG with allyl glycidyl ether. The synthesized copolymers are thermal initiated by autoclaving and grafted on plasma pretreated silicone surface, forming permanently bonded bottlebrush-like coatings. Both A-PHMG and APEG -PHMG coatings exhibit potent antimicrobial activity against gram-positive/negative bacteria and fungus, whereas APEG -PHMG coatings show superior antifouling activity and long-term reusability to A-PHMG coating. APEG -PHMG coating demonstrates the most effective in vitro antibiofilm and protein/platelet-resistant properties, as well as excellent hemo/biocompatibility. Furthermore, APEG -PHMG greatly reduces the bacteria number with 5-log reduction in a rodent subcutaneous infection model. This rationally designed dual-functional antimicrobial and antifouling coating has great potential in combating biomedical devices/implant-associated infections.

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Structural, thermal and antibacterial properties of polyamide 11/polymeric biocide polyhexamethylene guanidine dodecylbenzenesulfonate composites

Cited by 24 publications

References 35 publications

Antibiofilm Activity of Polyamide 11 Modified with Thermally Stable Polymeric Biocide Polyhexamethylene Guanidine 2-Naphtalenesulfonate

Antibiofilm Activity of Polyamide 11 Modified with Thermally Stable Polymeric Biocide Polyhexamethylene Guanidine 2-Naphtalenesulfonate

Antimicrobial Polymers in the Nano-World

Autoclaving‐Derived Surface Coating with In Vitro and In Vivo Antimicrobial and Antibiofilm Efficacies

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