Structural, theoretical investigations and HSA-interaction studies of three new copper(II) isothiosemicarbazone complexes

Alizadeh, Shabnam; Mague, Joel T.; Takjoo, Reza

doi:10.1016/j.poly.2022.115986

Cited by 1 publication

(1 citation statement)

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“…In some cases isothiosemicarbazones and their copper(II) coordination compounds outperform in activity the complexes of corresponding thiosemicarbazones [21]. Copper(II) complexes with isothiosemicarbazones are less often described in the literature [22][23][24] and there are several references to their biological activity, such as antibacterial [25,26] and anticancer [27,28].…”

Section: Introductionmentioning

confidence: 99%

Novel Copper(II) Complexes with N4,S-Diallylisothiosemicarbazones as Potential Antibacterial/Anticancer Drugs

et al. 2023

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The six new copper(II) coordination compounds [Cu(HL1)Cl2] (1), [Cu(HL1)Br2] (2), [Cu(H2O)(L1)(CH3COO)]·1.75H2O (3), [Cu(HL2)Cl2] (4), [Cu(HL2)Br2] (5), [Cu(H2O)(L2)(CH3COO)] (6) were synthesized with 2-formyl- and 2-acetylpyridine N4,S-diallylisothiosemicarbazones (HL1 and HL2). The new isothiosemicarbazones were characterized by NMR, FTIR spectroscopy, and X-ray crystallography ([H2L2]I). All copper(II) coordination compounds were characterized by elemental analysis, FTIR spectroscopy, and molar conductivity of their 1mM methanol solutions. Furthermore, the crystal structure of complex 3 was determined using single-crystal X-ray diffraction analysis. The studied complexes manifest antibacterial and antifungal activities, that in many cases are close to the activity of medical drugs used in this area, and in some cases even exceed them. The complexes 4 and 5 showed the highest indexes of selectivity (280 and 154) and high antiproliferative activity against BxPC-3 cell lines that surpass the activity of Doxorubicin. The complexes 1–3 also manifest antioxidant activities against cation radicals ABTS•+ that are close to that of trolox, the antioxidant agent used in medicine.

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