Structural tendon changes in patients with acromegaly: assessment of Achilles tendon with sonoelastography.

Önal, Eda Demir; İpek, Ali; Evranos, Berna; İdilman, İlkay S.; Çakır, Bekir; Ersoy, Reyhan

doi:10.11152/mu.2013.2066.181.edo

Cited by 8 publications

(9 citation statements)

References 18 publications

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“…However, in the same study, it was reported that there was no relationship between serum GH and IGF-1 level and this increased stiffness in the Achilles tendon. [22] In our study, Achilles tendon evaluation was not performed, but TGE evaluation was similarly performed and it was found that the tissue stiffness increased similarly to the previous study. Unlike the previous study, increased organ stiffness was independently associated with serum IGF-1 levels.…”

Section: Discussionsupporting

confidence: 75%

“…We found that thyroid gland stiffness was significantly increased in patients with acromegaly in our study. Recently, Onal et al [22] reported that the Achilles tendon thickness and tendon stiffness (grade II intermediate elasticity) obtained by SE were higher in patients with acromegaly with active disease. However, in the same study, it was reported that there was no relationship between serum GH and IGF-1 level and this increased stiffness in the Achilles tendon.…”

Section: Discussionmentioning

confidence: 99%

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Elastography detected solid organ stiffness increased in patients with acromegaly

Bankır¹,

Sümbül²,

Koç

et al. 2019

Medicine

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Elastography is a method to examine the increase in solid organs stiffness (SOS), and there is no data in the literature regarding to its use in patients with acromegaly. In this study, we aimed to investigate the change of SOS in patients with acromegaly and to determine the parameters closely related to SOS in same patient groups.We included 40 subjects with acromegaly and 40 healthy control subjects. In addition to routine renal, liver and thyroid ultrasonography (USG), SOS for 3 solid organs were measured by elastography. The participants of the study were divided into 3 groups as the control (Group-I), acromegaly patients with remission (Group-II), and acromegaly patients without remission (Group-III).Insulin growth factor-1 (IGF-1) level significantly increased from Group-I to Group-III. Glucose, creatinine, albuminuria, alkaline phosphatase, TSH, and growth factor levels were highest in Group-III and statistically significance was found only between Group-I and Group-III. Liver, kidney and thyroid size and echogenicity were increased from Group-I to Group-III. Liver and renal stiffness and thyroid gland strain ratio significantly increased from Group-I to Group-III and these parameters were statistically different between all groups. In linear regression analysis, IGF-1 levels were independent determinants of SOS.SOS values of acromegaly patients with active disease were significantly increased compared to both the control group and the acromegaly patients in remission phase. Serum IGF-1 levels were independently associated with SOS in these patients. SOS measurement should be part of a routine USG examination in patients with acromegaly, especially in patients during active disease.

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Elastography detected solid organ stiffness increased in patients with acromegaly

Bankır¹,

Sümbül²,

Koç

et al. 2019

Medicine

View full text Add to dashboard Cite

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“… SR had a negative correlation with functional score ( ρ = − 0.42, p = 0.03). Onal et al 2016 [ 35 ] 42 acromegaly patients/84 tendons. 42 healthy volunteers/84 tendons.…”

Section: Resultsmentioning

confidence: 99%

“…USE has also been studied in systemic diseases. A stiffness reduction of the Achilles tendon was observed in patients with ankylosing spondylitis [ 32 ], in diabetic patients with foot ulcers [ 33 ] and in acromegaly patients [ 35 ].…”

Section: Resultsmentioning

confidence: 99%

Ultrasound elastography: compression elastography and shear-wave elastography in the assessment of tendon injury

et al. 2018

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Ultrasound elastography (USE) is a recent technology that has experienced major developments in the past two decades. The assessment of the main mechanical properties of tissues can be made with this technology by characterisation of their response to stress. This article reviews the two major techniques used in musculoskeletal elastography, compression elastography (CE) and shear-wave elastography (SWE), and evaluates the studies published on major electronic databases that use both techniques in the context of tendon pathology. CE accounts for more studies than SWE. The mechanical properties of tendons, particularly their stiffness, may be altered in the presence of tendon injury. CE and SWE have already been used for the assessment of Achilles tendons, patellar tendon, quadriceps tendon, epicondylar tendons and rotator cuff tendons and muscles. Achilles tendinopathy is the most studied tendon injury with USE, including the postoperative period after surgical repair of Achilles rupture tendon. In relation to conventional ultrasound (US), USE potentially increases the sensitivity and diagnostic accuracy in tendinopathy, and can detect pathological changes before they are visible in conventional US imaging. Several technical limitations are recognised, and standardisation is necessary to ensure repeatability and comparability of the results when using these techniques. Still, USE is a promising technique under development and may be used not only to promote an early diagnosis, but also to identify the risk of injury and to support the evaluation of rehabilitation interventions.Key Points• USE is used for the assessment of the mechanical properties of tissues, including the tendons.• USE increases diagnostic performance when coupled to conventional US imaging modalities.• USE will be useful in early diagnosis, tracking outcomes and monitoring treatments of tendon injury.• Technical issues and lack of standardisation limits USE use in the assessment of tendon injury.

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“…Onal et al reported that patients with acromegaly had thicker tendon than healthy subjects, especially in active phase of disease. SE analysis showed an equal distribution of hard and soft patterns, however the analysis revealed a prevalence of intermediate pattern 43 .…”

Section: Other Pathologic Conditions Of the Achilles Tendonmentioning

confidence: 96%

Real-time sonoelastography: principles and clinical applications in tendon disorders.

Fusini

Langella

Busilacchi

et al. 2017

MLTJ

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SummaryBackground: Sonoelastography (SE) is a new ultrasound-based method adopted in an increased number of scientific reports to analyse normal and pathological tendons. The aim of this study is to provide a systematic overview of clinical applications of SE in normal and pathological tendons. Methods: A systematic research of PubMed, Ovid, and Cochrane Library electronic databases was performed according to PRISMA guideline. Two Authors searched and evaluated the articles independently; a third Author was involved to solve any disagreement. The Oxford Level of Evidence (LoE) was used to assess each article. Results. There is an increasing interest in the application of SE in the evaluation of healthy and diseased tendons. Many different tendons are amenable for SE evaluation, such as the Achilles and patellar tendons, rotator cuff, common extensor tendons, quadriceps tendon, and the plantar fascia.Conclusion. SE appears to be a very useful diagnostic tool, in particular in tendon pathology. This is a dynamic examination, provides an immediate evaluation of the tissue elasticity, and may be useful in recognizing tendon abnormalities and in implementing the information available with conventional US. Level of evidence: IV.

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Structural tendon changes in patients with acromegaly: assessment of Achilles tendon with sonoelastography.

Cited by 8 publications

References 18 publications

Elastography detected solid organ stiffness increased in patients with acromegaly

Elastography detected solid organ stiffness increased in patients with acromegaly

Ultrasound elastography: compression elastography and shear-wave elastography in the assessment of tendon injury

Real-time sonoelastography: principles and clinical applications in tendon disorders.

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