Structural study of picolinamide complexes of Ni(II), Zn(II), Cd(II), and Hg(II) nitrates in solid state and solution

Đaković, Marijana; Vinković, Marijana; Roca, Sunčica; Popović, Zora; Vicković, I.; Vikić‐Topić, Dražen; Lukač, Josip; Đaković, Nikola; Kusić, Zvonko

doi:10.1080/00958972.2012.663912

Cited by 22 publications

(6 citation statements)

References 49 publications

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“…Further studies with chloride or squarate acting as the counter‐ion confirmed this trans geometry [37,38] . The corresponding Ni(II) and Zn(II) aqua complexes also display a trans geometry [39] . Upon changing the axial aqua ligands to thiocyanate, a neutral cobalt complex is formed and the geometry switches to a cis arrangement, with the pyridyl rings remaining trans to one another [40] .…”

Section: Introductionmentioning

confidence: 81%

Bis(N‐picolinamido)cobalt(II) Complexes Display Antifungal Activity toward Candida albicans and Aspergillus fumigatus

et al. 2021

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This report highlights the synthesis and characterization of ten new bis(N‐picolinamido)cobalt(II) complexes of the type [(L)2CoX2]0/2+, whereby L=N‐picolinamide ligand and X=diisothiocyanato (−NCS), dichlorido (−Cl) or diaqua (−OH2) ligands. Single crystal X‐ray (SC‐XRD) analysis for nine of the structures are reported and confirm the picolinamide ligand is bound to the Co(II) center through a neutral N,O binding mode. With the addition of powder X‐ray diffraction (PXRD), we have confirmed the cis and trans ligand arrangements of each complex. All complexes were screened against several fungal species and show increased antifungal activity. Notably, these complexes had significant activity against strains of Candida albicans and Aspergillus fumigatus, with several compounds exhibiting growth inhibition of >80 %, and onecompound inhibiting Aspergillus fumigatus hyphal growth by >90 %. Conversely, no antifungal activity was exhibited toward Cryptococcus neoformans and no cytotoxicity towards mammalian cell lines.

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Section: Introductionmentioning

confidence: 81%

Bis(N‐picolinamido)cobalt(II) Complexes Display Antifungal Activity toward Candida albicans and Aspergillus fumigatus

et al. 2021

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“…Cu II has been reported to readily form an N , N ‐chelate with picolinamide, with concomitant deprotonation of the amide nitrogen under physiological conditions . In DMSO, the bis‐picolinamide complex of Hg II has been proposed to involve N , O ‐chelation and the respective Ni II and Zn II complexes unidentate coordination to the pyridine nitrogen . Solution data are not available for picolinamide complexes of Ag I but given the preference of Ag I for linear complexes, unidentate coordination to the pyridine nitrogen appears likely in this case as well.…”

Section: Resultsmentioning

confidence: 99%

Metal‐Dependent Nucleobase Recognition by Picolinamide

2016

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A C‐nucleoside featuring picolinamide as the base moiety has been synthesized and incorporated in the middle of a DNA oligonucleotide. The melting temperatures of duplexes formed by this modified oligonucleotide with its unmodified counterparts placing either adenine, cytosine, guanine or thymine opposite to the picolinamide residue were found to be highly dependent on the identity and concentration of transition metal ions in the samples. For example, AgI uniquely promoted pairing with adenine and PdII with guanine. Pairing with cytosine, on the other hand, was retarded by all of the metal ions studied (AgI, CuII, HgII, NiII, PdII and ZnII).

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“…47 The vibrations of water for both the compounds and the nitrate in the lattice of 1 are observed in the expected positions. 48,49 3.3 Electronic spectra of 1 and 2…”

Section: Infrared Spectroscopymentioning

confidence: 99%

Solvent-driven structural topology involving energetically significant intra- and intermolecular chelate ring contacts and anticancer activities of Cu(ii) phenanthroline complexes involving benzoates: experimental and theoretical studies

et al. 2019

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Structural study of picolinamide complexes of Ni(II), Zn(II), Cd(II), and Hg(II) nitrates in solid state and solution

Cited by 22 publications

References 49 publications

Bis(N‐picolinamido)cobalt(II) Complexes Display Antifungal Activity toward Candida albicans and Aspergillus fumigatus

Bis(N‐picolinamido)cobalt(II) Complexes Display Antifungal Activity toward Candida albicans and Aspergillus fumigatus

Metal‐Dependent Nucleobase Recognition by Picolinamide

Solvent-driven structural topology involving energetically significant intra- and intermolecular chelate ring contacts and anticancer activities of Cu(ii) phenanthroline complexes involving benzoates: experimental and theoretical studies

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