Structural studies on thiosalicylate complexes of Zn(II) &amp; Hg(II). First insight into Zn(II)-thiosalicylate complex as potential antibacterial, antibiofilm and anti-tumour agent

Singh, Ashish; Prakash, Pradyot; Kant, Rajni; Bhattacharya, Subrato

doi:10.1016/j.ica.2019.119263

Cited by 11 publications

(4 citation statements)

References 54 publications

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“…The peaks of Zn‐MBA at about 251 and 301 nm corresponded to the π→π* transition of benzene ring (Figure S25, Supporting Information). [ 24 ] Peak shifts and absorption maxima that are shifted to higher energy indicate that the spectra of these materials would show additional overlapping absorptions bands if other metal complexes resided in the pores; the lack of such electronic absorption features further supported the assertion that substitution occurs at the metal nodes. [ 23 ] XRD patterns of the Zn‐MBA materials after metathesis, shown in Figure 5b, confirm that the material retained the Zn‐MBA crystal structure, and discrepancies in peak intensities are due to preferential orientation.…”

Section: Resultsmentioning

confidence: 96%

Suppression of Vanadium Oxide Dissolution via Cation Metathesis within a Coordination Supramolecular Network for Durable Aqueous Zn‐V₂O₅ Batteries

Tao

Cui

Tan

et al. 2023

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Aqueous zinc metal batteries (ZMBs) are a promising sustainable technology for large‐scale energy storage applications. However, the water is often associated with problematic parasitic reactions on both anode and cathode, leading to the low durability and reliability of ZMBs. Here, a multifunctional separator for the Zn‐V2O5 batteries by growing the coordination supramolecular network (CSN:Zn‐MBA, MBA = 2‐mercaptobenzoic acid) on the conventional non‐woven fabrics (NWF) is developed. CSN tends to form a stronger coordination bond as a softer cation, enabling a thermodynamically preferred Zn2+ to VO2+ substitution in the network, leading to the formation of VO2‐MBA interface, that strongly obstructs the VO2(OH)2− penetration but simultaneously allows Zn2+ transfer. Moreover, Zn‐MBA molecules can adsorb the OTF− and distribute the interfacial Zn2+ homogeneous, which facilitate a dendrite‐free Zn deposition. The Zn‐V2O5 cells with Zn‐MBA@NWF separator realize high capacity of 567 mAh g−1 at 0.2 A g−1, and excellent cyclability over 2000 cycles with capacity retention of 82.2% at 5 A g−1. This work combines the original advantages of the template and new function of metals via cation metathesis within a CSN, provides a new strategy for inhibiting vanadium oxide dissolution.

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Section: Resultsmentioning

confidence: 96%

Suppression of Vanadium Oxide Dissolution via Cation Metathesis within a Coordination Supramolecular Network for Durable Aqueous Zn‐V₂O₅ Batteries

Tao

Cui

Tan

et al. 2023

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“…Moreover, the complex with mixed ligands [Zn(tsa)(tmeda)] 2 ( 65 ) (Htsa: thiosalicylic acid; tmeda: N , N , N ′, N ′-tetramethylethylenediamine) is very active on the old biofilms of S. aureus , as indicated in the studies performed by confocal laser scanning microscopy which revealed its bactericidal activities, possibly by membrane alterations, as demonstrated by the propidium iodide (PI) uptake [ 142 ].…”

Section: Complexes With Antibiofilm Activitymentioning

confidence: 99%

Metal Complexes—A Promising Approach to Target Biofilm Associated Infections

2022

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Microbial biofilms are represented by sessile microbial communities with modified gene expression and phenotype, adhered to a surface and embedded in a matrix of self-produced extracellular polymeric substances (EPS). Microbial biofilms can develop on both prosthetic devices and tissues, generating chronic and persistent infections that cannot be eradicated with classical organic-based antimicrobials, because of their increased tolerance to antimicrobials and the host immune system. Several complexes based mostly on 3D ions have shown promising potential for fighting biofilm-associated infections, due to their large spectrum antimicrobial and anti-biofilm activity. The literature usually reports species containing Mn(II), Ni(II), Co(II), Cu(II) or Zn(II) and a large variety of multidentate ligands with chelating properties such as antibiotics, Schiff bases, biguanides, N-based macrocyclic and fused rings derivatives. This review presents the progress in the development of such species and their anti-biofilm activity, as well as the contribution of biomaterials science to incorporate these complexes in composite platforms for reducing the negative impact of medical biofilms.

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“…Thiosalicylate complexes of Zn(II) and Hg(II), [Zn(SC 6 H 4 CO 2 )(TMEDA)] 2 , were shown to have potent antimicrobial and antibiofilm activities against E. coli , whereby complete degradation of E. coli biofilms was achieved at relatively small concentration of 0.227 μg/mL. Hence, the study suggested that the complexes hold great promise for the development of a new class of antibacterial and antibiofilm agents to combat the resistant pathogens [ 72 ]. Thiosalicylate complexes of Zn(II) and Hg(II), [Zn(SC 6 H 4 CO 2 )(TMEDA)] 2 , were also shown to exert anti-tumor actions against the colon cancer cell line HCT116 [ 72 ].…”

Section: Strategies To Target Gut Microbial Biofilmsmentioning

confidence: 99%

“…Hence, the study suggested that the complexes hold great promise for the development of a new class of antibacterial and antibiofilm agents to combat the resistant pathogens [ 72 ]. Thiosalicylate complexes of Zn(II) and Hg(II), [Zn(SC 6 H 4 CO 2 )(TMEDA)] 2 , were also shown to exert anti-tumor actions against the colon cancer cell line HCT116 [ 72 ]. Thus, it is worthwhile exploring the clinical use of thiosalicylate complexes as promising agents for preventing CRC.…”

Section: Strategies To Target Gut Microbial Biofilmsmentioning

confidence: 99%

Targeting Gut Microbial Biofilms—A Key to Hinder Colon Carcinogenesis?

Chew

Tan

Law

et al. 2020

Cancers

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Colorectal cancer (CRC) is a global public health issue which poses a substantial humanistic and economic burden on patients, healthcare systems and society. In recent years, intestinal dysbiosis has been suggested to be involved in the pathogenesis of CRC, with specific pathogens exhibiting oncogenic potentials such as Fusobacterium nucleatum, Escherichia coli and enterotoxigenic Bacteroides fragilis having been found to contribute to CRC development. More recently, it has been shown that initiation of CRC development by these microorganisms requires the formation of biofilms. Gut microbial biofilm forms in the inner colonic mucus layer and is composed of polymicrobial communities. Biofilm results in the redistribution of colonic epithelial cell E-cadherin, increases permeability of the gut and causes a loss of function of the intestinal barrier, all of which enhance intestinal dysbiosis. This literature review aims to compile the various strategies that target these pathogenic biofilms and could potentially play a role in the prevention of CRC. We explore the potential use of natural products, silver nanoparticles, upconverting nanoparticles, thiosalicylate complexes, anti-rheumatic agent (Auranofin), probiotics and quorum-sensing inhibitors as strategies to hinder colon carcinogenesis via targeting colon-associated biofilms.

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Structural studies on thiosalicylate complexes of Zn(II) & Hg(II). First insight into Zn(II)-thiosalicylate complex as potential antibacterial, antibiofilm and anti-tumour agent

Cited by 11 publications

References 54 publications

Suppression of Vanadium Oxide Dissolution via Cation Metathesis within a Coordination Supramolecular Network for Durable Aqueous Zn‐V₂O₅ Batteries

Suppression of Vanadium Oxide Dissolution via Cation Metathesis within a Coordination Supramolecular Network for Durable Aqueous Zn‐V₂O₅ Batteries

Metal Complexes—A Promising Approach to Target Biofilm Associated Infections

Targeting Gut Microbial Biofilms—A Key to Hinder Colon Carcinogenesis?

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Structural studies on thiosalicylate complexes of Zn(II) & Hg(II). First insight into Zn(II)-thiosalicylate complex as potential antibacterial, antibiofilm and anti-tumour agent

Cited by 11 publications

References 54 publications

Suppression of Vanadium Oxide Dissolution via Cation Metathesis within a Coordination Supramolecular Network for Durable Aqueous Zn‐V2O5 Batteries

Suppression of Vanadium Oxide Dissolution via Cation Metathesis within a Coordination Supramolecular Network for Durable Aqueous Zn‐V2O5 Batteries

Metal Complexes—A Promising Approach to Target Biofilm Associated Infections

Targeting Gut Microbial Biofilms—A Key to Hinder Colon Carcinogenesis?

Contact Info

Product

Resources

About

Suppression of Vanadium Oxide Dissolution via Cation Metathesis within a Coordination Supramolecular Network for Durable Aqueous Zn‐V₂O₅ Batteries

Suppression of Vanadium Oxide Dissolution via Cation Metathesis within a Coordination Supramolecular Network for Durable Aqueous Zn‐V₂O₅ Batteries