Abstract:Protein tyrosine phosphatases (PTPs) regulate cell signaling pathways implicated in cancers, diabetes, immune diseases, and neurological diseases. Although PTPs are drug targets, inhibitor development has been limited by the low selectivity caused by the shallow PTP active site pocket with a conserved motif. Recent studies on PTP inhibitors have highlighted allosteric inhibition to circumvent these difficulties. PTPσ is a receptor-type PTP with phosphatase activity in the cytoplasmic region. PTPσ plays a criti… Show more
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