Structural studies of phosphorinanes

Abstract

PART II. THE X-RAY CRYSTAL STRUCTURE OF CYCLOPHOSPHAMIDE 176 6. Keto-enol equilibria of isomeric hydrogen phosphonates 176a and b 7. Enol-intermediate isomerization mechanism of hydrogen phosphonates 176a and b 8. Keto-intermediate isomerization mechanism of hydrogen phosphonates 176a and b vii Page 9. Mechanism of hydrolysis of hydrogen phosphonate 176b to form phosphorous acid and meso-diol 154 10. Mechanism for formation of acetone insertion product of hydrogen phosphonate 176b 156 11. Computer drawing of cyclophosphamide excluding hydrogen atoms 187 12. Drawing of cyclophosphamide including hydrogen atoms 189 13. Computer drawing of the hydrogen bonding of the water of hydration to cyclophosphamide. The chloromethyl groups of the bis-(3-chloroethyl) groups and the hydrogen atoms of cyclophosphamide not involved in hydrogen bonding have been omitted for clarity 194 14. Computer drawing of unit cell of cyclophosphamide including two water molecules. Hydrogen atoms are omitted 197 PART I. SOLUTION STUDIES